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dc.contributor.authorYoung, Paul J-
dc.contributor.authorBellomo, Rinaldo-
dc.contributor.authorBernard, Gordon R-
dc.contributor.authorNiven, Daniel J-
dc.contributor.authorSchortgen, Frederique-
dc.contributor.authorSaxena, Manoj-
dc.contributor.authorBeasley, Richard-
dc.contributor.authorWeatherall, Mark-
dc.identifier.citationIntensive Care Medicine 2019; 45(4): 468-476-
dc.description.abstractOne potential way to protect patients from the physiological demands that are a consequence of fever is to aim to prevent fever and to treat it assiduously when it occurs. Our primary hypothesis was that more active fever management would increase survival among patient subgroups with limited physiological reserves such as older patients, patients with higher illness acuity, and those requiring organ support. We conducted an individual-level patient data meta-analysis of randomised controlled trials to compare the outcomes of ICU patients who received more active fever management with the outcomes of patients who received less active fever management. The primary outcome variable of interest was the unadjusted time to death after randomisation. Of 1413 trial participants, 707 were assigned to more active fever management and 706 were assigned to less active fever management. There was no statistically significant heterogeneity in the effect of more active compared with less active fever management on survival in any of the pre-specified subgroups that were chosen to identify patients with limited physiological reserves. Overall, more active fever management did not result in a statistically significant difference in survival time compared with less active fever management [hazard ratio 0.91; (95% CI 0.75-1.10), P = 0.32]. Our findings do not support the hypothesis that more active fever management increases survival compared with less active fever management overall or in patients with limited physiological reserves.-
dc.subjectNon-steroidal anti-inflammatory drugs-
dc.subjectPhysical cooling-
dc.subjectSeptic shock-
dc.titleFever control in critically ill adults. An individual patient data meta-analysis of randomised controlled trials.-
dc.typeJournal Article-
dc.identifier.journaltitleIntensive Care Medicine-
dc.identifier.affiliationVanderbilt University Medical Center, Nashville, TN, USA-
dc.identifier.affiliationDepartment of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada-
dc.identifier.affiliationAdult Intensive Care Unit, Centre Hospitalier Intercommunal de Créteil, Créteil, France-
dc.identifier.affiliationMedical Research Institute of New Zealand, Wellington, New Zealand.en
dc.identifier.affiliationThe George Institute for Global Health, Sydney, Australiaen
dc.identifier.affiliationBankstown Hospital, University of New South Wales, South Western Sydney Local Health District, Sydney, NSW, Australiaen
dc.identifier.affiliationAustin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationUniversity of Otago, Wellington, New Zealanden
dc.identifier.affiliationMedical Research Institute of New Zealand, Wellington, New Zealanden
dc.identifier.affiliationIntensive Care Unit, Wellington Hospital, Capital and Coast District Health Board, Wellington, New Zealand.en
dc.type.austinJournal Article-, Rinaldo
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.languageiso639-1en- Care- Analytics Research and Evaluation (DARE) Centre-
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