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Title: Speech and language in bilateral perisylvian polymicrogyria: a systematic review.
Austin Authors: Braden, Ruth O;Leventer, Richard J;Jansen, Anna;Scheffer, Ingrid E ;Morgan, Angela T
Affiliation: The Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia
Pediatric Neurology Unit, Department of Pediatrics, University Hospital Brussels, Brussels, Belgium
Murdoch Children's Research Institute, Parkville, Melbourne, Victoria, Australia
Neurogenetics Research Group, Reproduction Genetics and Regenerative Medicine Research Cluster, Vrije Universiteit Brussel, Brussels, Belgium
Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Melbourne, Victoria, Australia
Royal Children's Hospital, Parkville, Melbourne, Victoria, Australia
Austin Health, Heidelberg, Victoria, Australia
Issue Date: 2019 2019-01-25
Publication information: Developmental medicine and child neurology 2019; 61(10): 1145-1152
Abstract: We aimed to systematically review the speech production, language, and oral function phenotype of bilateral perisylvian polymicrogyria (BPP), and examine the correlation between the topography of polymicrogyria and the severity of speech, language, and oral functional impairment. A systematic search of MEDLINE, Embase, and PubMed databases was completed on 26th October 2017 using Medical Subject Heading terms synonymous with BPP and speech, language, or oral motor impairment. In total, 2411 papers were identified and 48 met inclusion criteria. Expressive and receptive language impairment and oral structural and functional deficits are frequent in BPP. Expressive deficits are frequently more severe than receptive. Only one study used formal assessments to demonstrate the presence of speech disorder, namely dysarthria. Seven studies reported an association between diffuse BPP and more severe language impairment. Findings confirmed that language deficits are common in BPP, though assessment of the specific speech phenotype is limited. The paucity of high quality studies detailing the specific communication phenotype of BPP highlights the need for further investigation. Improving understanding of this phenotype will inform the development of targeted therapies and lead to better long-term outcomes.
DOI: 10.1111/dmcn.14153
ORCID: 0000-0001-7730-1205
PubMed URL: 30680716
Type: Journal Article
Appears in Collections:Journal articles

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