Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/19974
Title: Centiloid scaling for quantification of brain amyloid with [18F]flutemetamol using multiple processing methods.
Austin Authors: Battle, Mark R;Pillay, Lovena Chedumbarum;Lowe, Val J;Knopman, David;Kemp, Bradley;Rowe, Christopher C ;Doré, Vincent ;Villemagne, Victor L ;Buckley, Christopher J
Affiliation: Mayo Clinic, Rochester, MN, USA
Austin Health, Heidelberg, Victoria, Australia
Imaging Technology Group, GE Healthcare, The Grove Centre, White Lion Road, Amersham, Buckinghamshire, UK
Issue Date: 5-Dec-2018
metadata.dc.date: 2018-12-05
Publication information: EJNMMI research 2018; 8 (107)
Abstract: A standardised method for quantifying β-amyloid PET tracers would allow comparison across different tracers and different sites. The development of the Centiloid scale has aimed to achieve this, applying a common scale to better aid the diagnosis and prognosis of Alzheimer's disease (AD) and to monitor anti-amyloid therapeutic interventions. Here, we apply the Centiloid method to [18F]flutemetamol and [11C]PiB (PiB, Pittsburgh compound B) PET images and derive the scaling factor to express their binding in Centiloids. Paired PiB and [18F]flutemetamol scans for 74 subjects, including 24 young healthy controls (37 ± 5 years), were analysed using the standard Centiloid method. The same subjects were also analysed using PMOD- and FSL-based pipelines as well as SPM8. Test-retest analysis of 10 AD subjects was also performed with each pipeline. The standard uptake value ratios (SUVR), determined using the standard SPM8 Centiloid process, showed a strong correlation between [18F]flutemetamol (Flute) and PiB binding (SUVR-Flute = 0.77 × SUVR-PiB + 0.22, R2 = 0.96). Application of the standard Centiloid process allowed the calculation of a direct conversion equation for SUVR-Flute to Centiloid units (CL) (CL = (121.42*SUVR-Flute) - 121.16). Analysis of the data via the two alternate Centiloid pipelines allowed us to derive standardised, SPM8-equivalent equations for both PMOD (CL = (115.24*SUVR-Flute) - 107.86) and FSL (CL = (120.32*SUVR-Flute) - 112.75) respectively. Test-retest analysis of 10 AD subjects showed an approximate 2% difference for each pipeline. [18F]flutemetamol data can now be expressed in Centiloid units, enhancing its utility in clinical and research applications for β-amyloid imaging. The standard Centiloid method also demonstrates that [18F]flutemetamol has favourable performance compared with PiB and other β-amyloid tracers. Test-retest difference averaged 2%, with no difference between image processing pipelines. Centiloid scaling is robust and can be implemented on a number of platforms.
URI: http://ahro.austin.org.au/austinjspui/handle/1/19974
DOI: 10.1186/s13550-018-0456-7
ORCID: 0000-0003-3910-2453
PubMed URL: 30519791
ISSN: 2191-219X
Type: Journal Article
Appears in Collections:Journal articles

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