Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/19922
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dc.contributor.authorWarrillow, Stephen J-
dc.contributor.authorBailey, Michael-
dc.contributor.authorPilcher, David-
dc.contributor.authorKazemi, Alex-
dc.contributor.authorMcArthur, Colin-
dc.contributor.authorYoung, Paul-
dc.contributor.authorBellomo, Rinaldo-
dc.date2018-11-27-
dc.date.accessioned2018-12-12T02:57:07Z-
dc.date.available2018-12-12T02:57:07Z-
dc.date.issued2019-07-
dc.identifier.citationInternal Medicine Journal 2019; 49(7): 874-885-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/19922-
dc.description.abstractKnowledge about patients with Acute Liver Failure (ALF) in Australia and New Zealand (ANZ) is lacking. We hypothesised that the pattern of disease would be similar to previous studies and that, despite low transplantation rates, mortality would be comparable. We obtained data from the ANZ Intensive Care Society Adult Patient Database and the ANZ Liver Transplant Registry for ten years commencing 2005 and analysed for patient outcomes. During the study period, 1 022 698 adults were admitted to intensive care units (ICUs) across ANZ, of which 723 had ALF. The estimated annual incidence of ALF over this period was 3.4/million people and increased over time (p=0.001). ALF patients had high illness severity (APACHE III 79.8 vs. 50.1 in non-ALF patients; p<0.0001), and were more likely to be younger, female, pregnant and immunosuppressed. ALF was an independent predictor of mortality (OR 1.5 (1.26-1.79); p<0.0001). At less than 23%, the use of liver transplantation was low, but the mortality of 39% was similar to previous studies. ALF is a rare but increasing diagnosis in ANZ ICUs. Low transplantation rates in ANZ for ALF do not appear to be associated with higher mortality rates than reported in the literature. This article is protected by copyright. All rights reserved.-
dc.language.isoeng-
dc.subjectacute liver failure-
dc.subjectemergency liver transplantation-
dc.subjectparacetamol overdose-
dc.titleCharacteristics and Outcomes of Patients with Acute Liver Failure Admitted to Australian and New Zealand Intensive Care Units.-
dc.typeJournal Article-
dc.identifier.journaltitleInternal Medicine Journal-
dc.identifier.affiliationSchool of Medicine, University of Melbourne, Melbourne, Australiaen
dc.identifier.affiliationMedical Research Institute of New Zealand, Auckland, New Zealanden
dc.identifier.affiliationIntensive Care Unit, Middlemore Hospital, South Auckland, New Zealanden
dc.identifier.affiliationIntensive Care Unit, Wellington Hospital, Wellington, New Zealanden
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Intensive Care, Alfred Health, Melbourne, Australiaen
dc.identifier.affiliationDepartment of Intensive Care Royal Melbourne Hospital, Melbourne, Australiaen
dc.identifier.affiliationData Analytics Research and Evaluation (DARE) Centre, Austin Health and The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Monash University School of Public Health and Preventive Medicine, Melbourne, Australiaen
dc.identifier.affiliationMedical Research Institute of New Zealand, Auckland, New Zealanden
dc.identifier.affiliationDepartment of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealanden
dc.identifier.doi10.1111/imj.14167-
dc.identifier.orcid0000-0002-7240-4106-
dc.identifier.orcid0000-0002-1650-8939-
dc.identifier.pubmedid30479057-
dc.type.austinJournal Article-
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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