Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/19922
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Warrillow, Stephen J | - |
dc.contributor.author | Bailey, Michael | - |
dc.contributor.author | Pilcher, David | - |
dc.contributor.author | Kazemi, Alex | - |
dc.contributor.author | McArthur, Colin | - |
dc.contributor.author | Young, Paul | - |
dc.contributor.author | Bellomo, Rinaldo | - |
dc.date | 2018-11-27 | - |
dc.date.accessioned | 2018-12-12T02:57:07Z | - |
dc.date.available | 2018-12-12T02:57:07Z | - |
dc.date.issued | 2019-07 | - |
dc.identifier.citation | Internal Medicine Journal 2019; 49(7): 874-885 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/19922 | - |
dc.description.abstract | Knowledge about patients with Acute Liver Failure (ALF) in Australia and New Zealand (ANZ) is lacking. We hypothesised that the pattern of disease would be similar to previous studies and that, despite low transplantation rates, mortality would be comparable. We obtained data from the ANZ Intensive Care Society Adult Patient Database and the ANZ Liver Transplant Registry for ten years commencing 2005 and analysed for patient outcomes. During the study period, 1 022 698 adults were admitted to intensive care units (ICUs) across ANZ, of which 723 had ALF. The estimated annual incidence of ALF over this period was 3.4/million people and increased over time (p=0.001). ALF patients had high illness severity (APACHE III 79.8 vs. 50.1 in non-ALF patients; p<0.0001), and were more likely to be younger, female, pregnant and immunosuppressed. ALF was an independent predictor of mortality (OR 1.5 (1.26-1.79); p<0.0001). At less than 23%, the use of liver transplantation was low, but the mortality of 39% was similar to previous studies. ALF is a rare but increasing diagnosis in ANZ ICUs. Low transplantation rates in ANZ for ALF do not appear to be associated with higher mortality rates than reported in the literature. This article is protected by copyright. All rights reserved. | - |
dc.language.iso | eng | - |
dc.subject | acute liver failure | - |
dc.subject | emergency liver transplantation | - |
dc.subject | paracetamol overdose | - |
dc.title | Characteristics and Outcomes of Patients with Acute Liver Failure Admitted to Australian and New Zealand Intensive Care Units. | - |
dc.type | Journal Article | - |
dc.identifier.journaltitle | Internal Medicine Journal | - |
dc.identifier.affiliation | School of Medicine, University of Melbourne, Melbourne, Australia | en |
dc.identifier.affiliation | Medical Research Institute of New Zealand, Auckland, New Zealand | en |
dc.identifier.affiliation | Intensive Care Unit, Middlemore Hospital, South Auckland, New Zealand | en |
dc.identifier.affiliation | Intensive Care Unit, Wellington Hospital, Wellington, New Zealand | en |
dc.identifier.affiliation | Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia | en |
dc.identifier.affiliation | Department of Intensive Care, Alfred Health, Melbourne, Australia | en |
dc.identifier.affiliation | Department of Intensive Care Royal Melbourne Hospital, Melbourne, Australia | en |
dc.identifier.affiliation | Data Analytics Research and Evaluation (DARE) Centre, Austin Health and The University of Melbourne, Heidelberg, Victoria, Australia | en |
dc.identifier.affiliation | Australian and New Zealand Intensive Care Research Centre, Monash University School of Public Health and Preventive Medicine, Melbourne, Australia | en |
dc.identifier.affiliation | Medical Research Institute of New Zealand, Auckland, New Zealand | en |
dc.identifier.affiliation | Department of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand | en |
dc.identifier.doi | 10.1111/imj.14167 | - |
dc.identifier.orcid | 0000-0002-7240-4106 | - |
dc.identifier.orcid | 0000-0002-1650-8939 | - |
dc.identifier.pubmedid | 30479057 | - |
dc.type.austin | Journal Article | - |
local.name.researcher | Bellomo, Rinaldo | |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Data Analytics Research and Evaluation (DARE) Centre | - |
Appears in Collections: | Journal articles |
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