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Title: Electrical stimulation of the piriform cortex for the treatment of epilepsy: A review of the supporting evidence.
Austin Authors: Young, James C;Vaughan, David N;Paolini, Antonio G;Jackson, Graeme D 
Affiliation: School of Psychology and Public Health, La Trobe University, Melbourne, Plenty Road and Kingsbury Drive, Bundoora, VIC 3068, Australia
Department of Neurology, Austin Health, Heidelberg, Victoria, Australia
ISN Psychology - Institute for Social Neuroscience, Melbourne, Level 6/10 Martin Street, Heidelberg, Victoria 3084, Australia
The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia
Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Parkville, Victoria, Australia
Issue Date: 27-Sep-2018
Date: 2018-09-27
Publication information: Epilepsy & behavior : E&B 2018; 88: 152-161
Abstract: In this review, we consider how the piriform cortex is engaged in both focal and generalized epilepsy networks and postulate the various neural pathways that can be effectively neuromodulated by stimulation at this site. This highlights the common involvement of the piriform cortex in epilepsy. We address both current and future preclinical studies of deep brain stimulation (DBS) of the piriform cortex, with attention to the critical features of these trials that will enable them to be of greatest utility in informing clinical translation. Although recent DBS trials have utilized thalamic targets, electrical stimulation of the piriform cortex may also be a useful intervention for people with epilepsy. However, more work is required to develop a solid foundation for this approach before considering human trials.
DOI: 10.1016/j.yebeh.2018.09.004
ORCID: 0000-0002-6225-7739
Journal: Epilepsy & behavior : E&B
PubMed URL: 30269034
Type: Journal Article
Subjects: Deep brain stimulation
Piriform cortex
Appears in Collections:Journal articles

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