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dc.contributor.authorRowe, Christopher C-
dc.contributor.authorJones, Gareth-
dc.contributor.authorDoré, Vincent-
dc.contributor.authorPejoska, Svetlana-
dc.contributor.authorMargison, Laura-
dc.contributor.authorMulligan, Rachel S-
dc.contributor.authorChan, J Gordon-
dc.contributor.authorYoung, Kenneth-
dc.contributor.authorVillemagne, Victor L-
dc.identifier.citationJournal of nuclear medicine : official publication, Society of Nuclear Medicine 2016; 57(8): 1233-1237en
dc.description.abstractA common quantitative output value for PET measures of β-amyloid (Aβ) binding across tracers and methods would allow better comparison of data across sites and application of universal diagnostic and prognostic values. A method has recently been developed that generates a unit of measurement called the centiloid. We applied this method to 2-[2-(18)F-fluoro-6-(methylamino)-3-pyridinyl]-1-benzofuran-5-ol ((18)F-NAV4694) and (11)C-Pittsburgh compound B ((11)C-PiB) Aβ images to derive the scaling factor required to express tracer binding in centiloids. Fifty-five participants, including 10 young controls (33 ± 7 y old), underwent both (11)C-PiB and (18)F-NAV4694 imaging no more than 3 mo apart, with the images acquired 50-70 min after tracer injection. The images were spatially normalized and analyzed using the standard centiloid method and regions (cortex and whole-cerebellum reference) downloaded from the Global Alzheimer Association Interactive Network website. SUV ratios (SUVRs) showed a strong correlation in tracer binding ((18)F-NAV4694 SUVR = 1.09 × (11)C-PiB SUVR - 0.08, R(2) = 0.99). The equation to convert (18)F-NAV4694 to centiloids [100 × ((18)F-NAV4694 SUVR - 1.028)/1.174] was similar to a published equation for (11)C-PiB [100 × ((11)C-PiB SUVR - 1.009)/1.067]. In the young controls, the variance ratio ((18)F-NAV4694 centiloid SD divided by (11)C-PiB centiloid SD) was 0.85. The results for both (11)C-PiB and (18)F-NAV4694 can now be expressed in centiloids, an important step that should allow better clinical and research use of Aβ imaging. The standard centiloid method also showed that (18)F-NAV4694 has slightly higher Aβ binding and lower variance than (11)C-PiB, important properties for detecting early Aβ deposition and change over time.en
dc.subjectAlzheimer’s diseaseen
dc.subjectamyloid imagingen
dc.titleStandardized Expression of 18F-NAV4694 and 11C-PiB β-Amyloid PET Results with the Centiloid Scale.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of nuclear medicine : official publication, Society of Nuclear Medicineen
dc.identifier.affiliationDepartment of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Melbourne, Australiaen
dc.identifier.affiliationAustralia CSIRO Health and Biosecurity, Brisbane, Australiaen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australiaen
dc.type.austinComparative Study-
dc.type.austinJournal Article-, J Gordon
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.languageiso639-1en- Imaging and Therapy- Imaging and Therapy- Imaging and Therapy- Imaging and Therapy- Imaging and Therapy- Imaging and Therapy- Imaging and Therapy-
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