Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/19201
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dc.contributor.authorFrench, Craig J-
dc.contributor.authorGlassford, Neil J-
dc.contributor.authorGantner, Dashiell-
dc.contributor.authorHiggins, Alisa M-
dc.contributor.authorCooper, David James-
dc.contributor.authorNichol, Alistair-
dc.contributor.authorSkrifvars, Markus B-
dc.contributor.authorImberger, Georgina-
dc.contributor.authorPresneill, Jeffrey-
dc.contributor.authorBailey, Michael-
dc.contributor.authorBellomo, Rinaldo-
dc.date.accessioned2018-09-13T00:21:11Z-
dc.date.available2018-09-13T00:21:11Z-
dc.date.issued2017-01-
dc.identifier.citationAnnals of surgery 2017; 265(1): 54-62-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/19201-
dc.description.abstractTo perform a meta-analysis of all relevant randomized controlled trials assessing the effect of erythropoiesis-stimulating agents (ESAs) in critically ill trauma patients. ESAs have effects beyond erythropoiesis. The administration of the ESA epoetin alfa to critically ill trauma patients has been associated with a reduction in mortality. We performed a systematic review and meta-analysis with trial sequential analysis. We searched Medline, Medline in Process, and other nonindexed citations, EMBASE, and the Cochrane Database from inception until September 9, 2015, for randomized controlled trials comparing ESAs to placebo (or no ESA). We identified 9 eligible studies that randomly assigned 2607 critically ill patients after trauma to an ESA or placebo (or no ESA). Compared with placebo (or no ESA), ESA therapy was associated with a substantial reduction in mortality [risk ratio (RR) 0.63, 95% confidence interval (CI) 0.49-0.79, P = 0.0001, I = 0%). In patients with traumatic brain injury, ESA therapy did not increase the number of patients surviving with moderate disability or good recovery (RR 1.00, 95% CI 0.88-1.15, P = 0.95, I = 0%). With the dosing regimens employed in the included studies, ESA therapy did not increase the risk of lower limb proximal deep venous thrombosis (RR 0.97, 95% CI 0.72-1.29, P = 0.78, I = 0%). The administration of ESAs to critically ill trauma patients is associated with a significant improvement in mortality without an increase in the rate of lower limb proximal deep venous thrombosis. Given the worldwide public health significance of these findings research to validate or refute them is required.-
dc.language.isoeng-
dc.titleErythropoiesis-stimulating Agents in Critically Ill Trauma Patients: A Systematic Review and Meta-analysis.-
dc.typeJournal Article-
dc.identifier.journaltitleAnnals of surgery-
dc.identifier.affiliationDivision of Intensive Care, Department of Anesthesiology, Intensive Care and Pain Medicine, Helsinki University Hospital and Helsinki University, Helsinki, Finlanden
dc.identifier.affiliationRoyal Brisbane and Women's Hospital, Brisbane, Australiaen
dc.identifier.affiliationThe University of Melbourne, Parkville, Melbourne, Australiaen
dc.identifier.affiliationDepartments of Anaesthesia and Intensive Care, Western Health, Gordon Street, Footscray, Melbourne, Australiaen
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australiaen
dc.identifier.affiliationDepartment of Intensive Care, The Alfred, Melbourne, Australiaen
dc.identifier.affiliationSt Vincent's University Hospital, Dublin, Irelanden
dc.identifier.doi10.1097/SLA.0000000000001746-
dc.identifier.orcid0000-0002-1650-8939-
dc.identifier.pubmedid27070933-
dc.type.austinJournal Article-
dc.type.austinMeta-Analysis-
dc.type.austinReview-
local.name.researcherBellomo, Rinaldo
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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