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dc.contributor.authorToner, Liam-
dc.contributor.authorPapa, Nathan-
dc.contributor.authorAliyu, Sani H-
dc.contributor.authorDev, Harveer-
dc.contributor.authorLawrentschuk, Nathan-
dc.contributor.authorAl-Hayek, Samih-
dc.identifier.citationInvestigative and clinical urology 2016; 57(2): 129-34-
dc.description.abstractEnterococci are a common cause of urinary tract infection and vancomycin-resistant strains are more difficult to treat. The purpose of this surveillance program was to assess the prevalence of and determine the risk factors for vancomycin resistance in adults among urinary isolates of Enterococcus sp. and to detail the antibiotic susceptibility profile, which can be used to guide empirical treatment. From 2005 to 2014 we retrospectively reviewed 5,528 positive Enterococcus sp. urine cultures recorded in a computerized laboratory results database at a tertiary teaching hospital in Cambridge, United Kingdom. Of these cultures, 542 (9.8%) were vancomycin resistant. No longitudinal trend was observed in the proportion of vancomycin-resistant strains over the course of the study. We observed emerging resistance to nitrofurantoin with rates climbing from near zero to 40%. Ampicillin resistance fluctuated between 50% and 90%. Low resistance was observed for linezolid and quinupristin/dalfopristin. Female sex and inpatient status were identified as risk factors for vancomycin resistance. The incidence of vancomycin resistance among urinary isolates was stable over the last decade. Although resistance to nitrofurantoin has increased, it still serves as an appropriate first choice in uncomplicated urinary tract infection caused by vancomycin-resistant Enterococcus sp.-
dc.subjectAntibiotic prophylaxis-
dc.subjectMicrobial drug resistance-
dc.subjectUrinary tract infection-
dc.subjectVancomycin-resistant enterococci-
dc.titleVancomycin resistant enterococci in urine cultures: Antibiotic susceptibility trends over a decade at a tertiary hospital in the United Kingdom.-
dc.typeJournal Article-
dc.identifier.journaltitleInvestigative and clinical urology-
dc.identifier.affiliationDepartment of Surgery, Urology Unit, University of Melbourne, Melbourne, Australia-
dc.identifier.affiliationDepartment of Microbiology, Addenbrookes' Hospital, Cambridge University, Cambridge, UK-
dc.identifier.affiliationDepartment of Urology, Addenbrookes' Hospital, Cambridge University, Cambridge, UK-
dc.identifier.affiliationOlivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia-
dc.identifier.affiliationDepartment of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia-
dc.type.austinJournal Article-, Liam
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
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