Austin Health

Title
A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort.
Publication Date
2017-10-25
Author(s)
Pedrini, Steve
Gupta, Veer B
Hone, Eugene
Doecke, James
O'Bryant, Sid
James, Ian
Bush, Ashley I
Rowe, Christopher C
Villemagne, Victor L
Ames, David
Masters, Colin L
Martins, Ralph N
Type of document
Journal Article
OrcId
0000-0003-2863-0293
0000-0001-8259-9069
0000-0003-3910-2453
DOI
10.1038/s41598-017-14020-9
Abstract
Alzheimer's Disease (AD) is the most common form of dementia, characterised by extracellular amyloid deposition as plaques and intracellular neurofibrillary tangles of tau protein. As no current clinical test can diagnose individuals at risk of developing AD, the aim of this project is to evaluate a blood-based biomarker panel to identify individuals who carry this risk. We analysed the levels of 22 biomarkers in clinically classified healthy controls (HC), mild cognitive impairment (MCI) and Alzheimer's participants from the well characterised Australian Imaging, Biomarker and Lifestyle (AIBL) study of aging. High levels of IL-10 and IL-12/23p40 were significantly associated with amyloid deposition in HC, suggesting that these two biomarkers might be used to detect at risk individuals. Additionally, other biomarkers (Eotaxin-3, Leptin, PYY) exhibited altered levels in AD participants possessing the APOE ε4 allele. This suggests that the physiology of some potential biomarkers may be altered in AD due to the APOE ε4 allele, a major risk factor for AD. Taken together, these data highlight several potential biomarkers that can be used in a blood-based panel to allow earlier identification of individuals at risk of developing AD and/or early stage AD for which current therapies may be more beneficial.
Link
Citation
Scientific Reports 2017; 7(1): 14057
Jornal Title
Scientific Reports

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