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Title: Diagnostic dilemma between medication-related osteonecrosis and oral squamous cell carcinoma in a mandibular lytic lesion.
Austin Authors: Tocaciu, S;Breik, O;Lim, B;Angel, C;Rutherford, N
Affiliation: Oral and Maxillofacial Surgery Unit, Austin Health, Heidelberg, Victoria, Australia
Department of Pathology, Peter McCallum Cancer Centre, Melbourne, Victoria
Issue Date: Nov-2017
Date: 2017-08-26
Publication information: The British journal of oral & maxillofacial surgery 2017; 55(9): e53-e57
Abstract: Osteolytic lesions of the mandible are common, and there are two important differential diagnoses that must be considered: medication-related osteonecrosis of the jaws (MRONJ) and squamous cell carcinoma (SCC). In patients with a history of taking antiresorptive medication as well as risk factors for neoplasia it can be difficult to differentiate between the two. We describe two cases in both of which a mandibular osteolytic lesion was inadequately identified as either MRONJ or SCC because of confusing clinical and histopathological features. We also reviewed relevant publications to identify similar cases. Here we discuss our clinical dilemma when faced with two different conditions that present with similar clinical and histopathological features.
DOI: 10.1016/j.bjoms.2017.08.005
Journal: The British journal of oral & maxillofacial surgery
PubMed URL: 28851496
Type: Journal Article
Subjects: Bisphosphonate related osteonecrosis of the jaws (BRONJ)
Medication-related osteonecrosis of the jaws (MRONJ)
squamous cell carcinoma (SCC)
Appears in Collections:Journal articles

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