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Title: Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts.
Austin Authors: Buckley, Rachel F;Mormino, Elizabeth C;Amariglio, Rebecca E;Properzi, Michael J;Rabin, Jennifer S;Lim, Yen Ying;Papp, Kathryn V;Jacobs, Heidi I L;Burnham, Samantha;Hanseeuw, Bernard J;Doré, Vincent ;Dobson, Annette;Masters, Colin L ;Waller, Michael;Rowe, Christopher C ;Maruff, Paul;Donohue, Michael C;Rentz, Dorene M;Kirn, Dylan;Hedden, Trey;Chhatwal, Jasmeer;Schultz, Aaron P;Johnson, Keith A;Villemagne, Victor L ;Sperling, Reisa A
Affiliation: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Heidelberg, Victoria, Australia
Melbourne School of Psychological Science, University of Melbourne, Victoria, Australia
Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA
Department of Neurology, Stanford University, CA, USA
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA
Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands
The Australian eHealth Research Centre, CSIRO Health & Biosecurity, Victoria, Australia
Department of Neurology, Cliniques Universitaires Saint-Luc, Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium
The University of Queensland, School of Public Health, Faculty of Medicine, Queensland, Australia
Department of Nuclear Medicine and Centre for PET, Austin Health, Victoria, Australia
Department of Medicine, Austin Health, The University of Melbourne, Victoria, Australia
Cogstate, Ltd., Australia
Department of Neurology, University of Southern California, San Diego, CA, USA
Issue Date: 2018 2018-05-24
Publication information: Alzheimer's & dementia : the journal of the Alzheimer's Association 2018; 14(9): 1193-1203
Abstract: Our objective was to investigate the effect of sex on cognitive decline within the context of amyloid β (Aβ) burden and apolipoprotein E genotype. We analyzed sex-specific effects on Aβ-positron emission tomography, apolipoprotein, and rates of change on the Preclinical Alzheimer Cognitive Composite-5 across three cohorts, such as the Alzheimer's Disease Neuroimaging Initiative, Australian Imaging, Biomarker and Lifestyle, and Harvard Aging Brain Study (n = 755; clinical dementia rating = 0; age (standard deviation) = 73.6 (6.5); female = 55%). Mixed-effects models of cognitive change by sex, Aβ-positron emission tomography, and apolipoprotein ε4 were examined with quadratic time effects over a median of 4 years of follow-up. Apolipoprotein ε4 prevalence and Aβ burden did not differ by sex. Sex did not directly influence cognitive decline. Females with higher Aβ exhibited faster decline than males. Post hoc contrasts suggested that females who were Aβ and apolipoprotein ε4 positive declined faster than their male counterparts. Although Aβ did not differ by sex, cognitive decline was greater in females with higher Aβ. Our findings suggest that sex may play a modifying role on risk of Alzheimer's disease-related cognitive decline.
DOI: 10.1016/j.jalz.2018.04.010
ORCID: 0000-0002-5356-5537
PubMed URL: 29803541
Type: Journal Article
Subjects: APOE
Cognitive decline
Preclinical Alzheimer's disease
Appears in Collections:Journal articles

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