Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/17962
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dc.contributor.authorSteigedal, Tonje S-
dc.contributor.authorToraskar, Jimita-
dc.contributor.authorRedvers, Richard P-
dc.contributor.authorValla, Marit-
dc.contributor.authorMagnussen, Synnøve N-
dc.contributor.authorBofin, Anna M-
dc.contributor.authorOpdahl, Signe-
dc.contributor.authorLundgren, Steinar-
dc.contributor.authorEckhardt, Bedrich L-
dc.contributor.authorLamar, John M-
dc.contributor.authorDoherty, Judy-
dc.contributor.authorHynes, Richard O-
dc.contributor.authorAnderson, Robin L-
dc.contributor.authorSvineng, Gunbjørg-
dc.date2018-03-11-
dc.date.accessioned2018-07-02T03:57:52Z-
dc.date.available2018-07-02T03:57:52Z-
dc.date.issued2018-04-
dc.identifier.citationNeoplasia (New York, N.Y.) 2018; 20(4): 387-400-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/17962-
dc.description.abstractMost cancer patients with solid tumors who succumb to their illness die of metastatic disease. While early detection and improved treatment have led to reduced mortality, even for those with metastatic cancer, some patients still respond poorly to treatment. Understanding the mechanisms of metastasis is important to improve prognostication, to stratify patients for treatment, and to identify new targets for therapy. We have shown previously that expression of nephronectin (NPNT) is correlated with metastatic propensity in breast cancer cell lines. In the present study, we provide a comprehensive analysis of the expression pattern and distribution of NPNT in breast cancer tissue from 842 patients by immunohistochemical staining of tissue microarrays from a historic cohort. Several patterns of NPNT staining were observed. An association between granular cytoplasmic staining (in <10% of tumor cells) and poor prognosis was found. We suggest that granular cytoplasmic staining may represent NPNT-positive exosomes. We found that NPNT promotes adhesion and anchorage-independent growth via its integrin-binding and enhancer motifs and that enforced expression in breast tumor cells promotes their colonization of the lungs. We propose that NPNT may be a novel prognostic marker in a subgroup of breast cancer patients.-
dc.language.isoeng-
dc.titleNephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs.-
dc.typeJournal Article-
dc.identifier.journaltitleNeoplasia (New York, N.Y.)-
dc.identifier.affiliationDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway-
dc.identifier.affiliationPeter MacCallum Cancer Centre, East Melbourne, Victoria, Australia-
dc.identifier.affiliationHoward Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, United Statesen
dc.identifier.affiliationDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States-
dc.identifier.affiliationCentral Norway Regional Health Authority, Stjørdal, Norwa-
dc.identifier.affiliationOlivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia-
dc.identifier.affiliationDepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Trondheim, Norway-
dc.identifier.affiliationDepartment of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway, Tromsø, Norway.-
dc.identifier.affiliationCancer Clinic, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway-
dc.identifier.affiliationMorgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas at MD Anderson Cancer Centre, Houston, TX, USA-
dc.identifier.affiliationSection of Translational Breast Cancer Research, The University of Texas at MD Anderson Cancer Centre, Houston, TX, USA-
dc.identifier.affiliationDepartment of Breast Medical Oncology, The University of Texas at MD Anderson Cancer Centre, Houston, TX 77030, USA-
dc.identifier.affiliationSchool of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia-
dc.identifier.affiliationDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA-
dc.identifier.doi10.1016/j.neo.2018.02.008-
dc.identifier.orcid0000-0002-6841-7422-
dc.identifier.orcid0000-0003-4527-7938-
dc.identifier.pubmedid29539586-
dc.type.austinJournal Article-
local.name.researcherAnderson, Robin L
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
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