Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/17864
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dc.contributor.authorLéopold, Valentine-
dc.contributor.authorGayat, Etienne-
dc.contributor.authorPirracchio, Romain-
dc.contributor.authorSpinar, Jindrich-
dc.contributor.authorParenica, Jiri-
dc.contributor.authorTarvasmäki, Tuukka-
dc.contributor.authorLassus, Johan-
dc.contributor.authorHarjola, Veli-Pekka-
dc.contributor.authorChampion, Sébastien-
dc.contributor.authorZannad, Faiez-
dc.contributor.authorValente, Serafina-
dc.contributor.authorUrban, Philip-
dc.contributor.authorChua, Horng-Ruey-
dc.contributor.authorBellomo, Rinaldo-
dc.contributor.authorPopovic, Batric-
dc.contributor.authorOuweneel, Dagmar M-
dc.contributor.authorHenriques, José P S-
dc.contributor.authorSimonis, Gregor-
dc.contributor.authorLévy, Bruno-
dc.contributor.authorKimmoun, Antoine-
dc.contributor.authorGaudard, Philippe-
dc.contributor.authorBasir, Mir Babar-
dc.contributor.authorMarkota, Andrej-
dc.contributor.authorAdler, Christoph-
dc.contributor.authorReuter, Hannes-
dc.contributor.authorMebazaa, Alexandre-
dc.contributor.authorChouihed, Tahar-
dc.date2018-06-01-
dc.date.accessioned2018-06-18T22:49:24Z-
dc.date.available2018-06-18T22:49:24Z-
dc.date.issued2018-
dc.identifier.citationIntensive Care Medicine 2018; 44(6): 847-856-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/17864-
dc.description.abstractCatecholamines have been the mainstay of pharmacological treatment of cardiogenic shock (CS). Recently, use of epinephrine has been associated with detrimental outcomes. In the present study we aimed to evaluate the association between epinephrine use and short-term mortality in all-cause CS patients. We performed a meta-analysis of individual data with prespecified inclusion criteria: (1) patients in non-surgical CS treated with inotropes and/or vasopressors and (2) at least 15% of patients treated with epinephrine administrated alone or in association with other inotropes/vasopressors. The primary outcome was short-term mortality. Fourteen published cohorts and two unpublished data sets were included. We studied 2583 patients. Across all cohorts of patients, the incidence of epinephrine use was 37% (17-76%) and short-term mortality rate was 49% (21-69%). A positive correlation was found between percentages of epinephrine use and short-term mortality in the CS cohort. The risk of death was higher in epinephrine-treated CS patients (OR [CI] = 3.3 [2.8-3.9]) compared to patients treated with other drug regimens. Adjusted mortality risk remained striking in epinephrine-treated patients (n = 1227) (adjusted OR = 4.7 [3.4-6.4]). After propensity score matching, two sets of 338 matched patients were identified and epinephrine use remained associated with a strong detrimental impact on short-term mortality (OR = 4.2 [3.0-6.0]). In this very large cohort, epinephrine use for hemodynamic management of CS patients is associated with a threefold increase of risk of death.-
dc.language.isoeng-
dc.subjectCardiogenic shock-
dc.subjectEpinephrine-
dc.subjectMeta-analysis-
dc.subjectPrognosis-
dc.titleEpinephrine and short-term survival in cardiogenic shock: an individual data meta-analysis of 2583 patients.-
dc.typeJournal Article-
dc.identifier.journaltitleIntensive Care Medicine-
dc.identifier.affiliationInvestigation Network Initiative - Cardiovascular and Renal Clinical Trialists, INI-CRCT, Nancy, Franceen
dc.identifier.affiliationDepartment of Anesthesiology and Critical Care, APHP - Saint Louis Lariboisière University Hospitals, University Paris Diderot and INSERM UMR-S 942, Paris, France-
dc.identifier.affiliationDepartment of Internal Medicine III, University of Cologne, Cologne, Germanyen
dc.identifier.affiliationDepartment of Anesthesiology and Critical Care Medicine, Hôpital Européen Georges Pompidou, Paris, France-
dc.identifier.affiliationCardiology Department, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic-
dc.identifier.affiliationHeart and Lung Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland-
dc.identifier.affiliationEmergency Medicine, University of Helsinki and Department of Emergency Medicine and Services, Helsinki University Hospital, Helsinki, Finland-
dc.identifier.affiliationIntensive Care Unit, University Hospital Félix Guyon, Saint Denis, France-
dc.identifier.affiliationCIC-Plurithématique, INSERM, University Hospital of Nancy, Nancy, France-
dc.identifier.affiliationIntensive Cardiac Care Unit, Florence University Hospital, Careggi, Florence, Italy-
dc.identifier.affiliationCardiovascular Department, Hôpital de la Tour, Meyrin-Geneva, Switzerland-
dc.identifier.affiliationIntensive Care Unit, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre (ANZIC RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia-
dc.identifier.affiliationSchool of Medicine, The University of Melbourne, Melbourne, Australia-
dc.identifier.affiliationDepartment of Intensive Care, Royal Melbourne Hospital, Melbourne, Australia-
dc.identifier.affiliationDivision of Nephrology, National University Health System, University Medicine Cluster, Singapore, Singapore-
dc.identifier.affiliationCardiology Department, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France-
dc.identifier.affiliationAMC Heart Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands-
dc.identifier.affiliationDepartment of Medicine/Cardiology, Heart Center Dresden University of Technology, Dresden, Germany-
dc.identifier.affiliationPraxisklinik Herz und Gefaesse, Dresden, Germany-
dc.identifier.affiliationIntensive Care Unit, Faculty of Medicine, University Hospital of Nancy, France, and U1116, Vandoeuvre-lès-Nancy, France-
dc.identifier.affiliationDepartment of Anesthesiology and Critical Care Medicine, PhyMedExp, University of Montpellier, INSERM, CNRS, Montpellier, France-
dc.identifier.affiliationDivision of Cardiology, Henry Ford Hospital, 2799W. Grand Blvd - K14, Detroit, MI, 48202, USA-
dc.identifier.affiliationMedical Intensive Care Unit, University Medical Centre Maribor, Ljubljanska, Maribor, Slovenia-
dc.identifier.affiliationEmergency Department, University Hospital of Nancy, Nancy, France-
dc.identifier.affiliationINSERM U1116, University of Lorraine, Nancy, France-
dc.identifier.doi10.1007/s00134-018-5222-9-
dc.identifier.orcid0000-0003-1379-0585-
dc.identifier.orcid0000-0002-1650-8939-
dc.identifier.pubmedid29858926-
dc.type.austinJournal Article-
dc.type.austinReview-
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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