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dc.contributor.authorMgaieth, S-
dc.contributor.authorKemp, W-
dc.contributor.authorGow, Paul J-
dc.contributor.authorFink, Michael A-
dc.contributor.authorLubel, J-
dc.contributor.authorNicoll, A-
dc.contributor.authorGazzola, A-
dc.contributor.authorHong, T-
dc.contributor.authorRyan, M-
dc.contributor.authorKnight, V-
dc.contributor.authorDev, A T-
dc.contributor.authorSood, S-
dc.contributor.authorBell, S-
dc.contributor.authorPaul, E-
dc.contributor.authorRoberts, S K-
dc.identifier.citationJournal of Viral Hepatitis 2017; 24(11): 982-989en_US
dc.description.abstractWhile HBV and HCV are risk factors for HCC, uncertainty exists as to whether these viral infections have prognostic significance in HCC. Thus, we compared the overall survival of patients with HBV, HCV and nonviral HCC, and evaluated whether the presence of HBV and HCV predicts patient outcomes. We conducted a multicentre study of HCC cases diagnosed at six Melbourne tertiary hospitals between Jan 2000-Dec 2014. Patient demographics, liver disease and tumour characteristics and patient outcomes were obtained from hospital databases, computer records and the Victorian Death Registry. Survival outcomes were compared between HBV, HCV and nonviral hepatitis cases and predictors of survival determined using Cox proportional hazards regression. There were 1436 new HCC cases identified including 776 due to viral hepatitis (HBV 235, HCV 511, HBV-HCV 30) and 660 from nonviral causes. The median survival of HBV, HCV and nonviral HCC patients was 59.1, 28.4 and 20.9 months, respectively (P<.0001). On multivariate analysis, independent risk factors for survival included HCC aetiology, gender, BCLC stage, serum AFP, total number and size of lesions, and serum creatinine and albumin. After adjusting for these and method of detection, HBV remained an independent predictor of improved overall survival when compared to both nonviral (HR 0.60%, 95% CI 0.35-0.98; P=.03) and HCV-related HCC (HR 0.51%, 95% CI 0.30-0.85; P=.01). In this large multicentre study, HBV is independently associated with improved overall survival compared with HCV and nonviral-related HCC. Further studies are needed to determine the underlying factor(s) responsible.en_US
dc.subjecthepatitis Ben_US
dc.subjecthepatitis Cen_US
dc.subjecthepatocellular carcinomaen_US
dc.titleImpact of viral hepatitis aetiology on survival outcomes in hepatocellular carcinoma: A large multicentre cohort study.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Viral Hepatitisen_US
dc.identifier.affiliationDepartment of Gastroenterology, Alfred Hospital, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationGastroenterology and Hepatologyen_US
dc.identifier.affiliationDepartment of Gastroenterology, Box Hill Hospital, Box Hill, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Gastroenterology, Royal Melbourne Hospital, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Gastroenterology, St Vincent's Hospital, Fitzroy, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Gastroenterology, Monash Medical Centre, Clayton, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australiaen_US
dc.type.austinJournal Article-
dc.type.austinMulticenter Study-, Michael A
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristype Liver Transplant Unit- and Hepatology- Liver Transplant Unit- Liver Transplant Unit-
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