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dc.contributor.authorShetty, Amith-
dc.contributor.authorMacdonald, Stephen Pj-
dc.contributor.authorKeijzers, Gerben-
dc.contributor.authorWilliams, Julian M-
dc.contributor.authorTang, Benjamin-
dc.contributor.authorde Groot, Bas-
dc.contributor.authorThompson, Kelly-
dc.contributor.authorFraser, John F-
dc.contributor.authorFinfer, Simon-
dc.contributor.authorBellomo, Rinaldo-
dc.contributor.authorIredell, Jonathan-
dc.identifier.citationEmergency Medicine Australasia : EMA 2018; 30(1): 4-12-
dc.description.abstractSepsis is characterised by organ dysfunction resulting from infection, with no reliable single objective test and current diagnosis based on clinical features and results of investigations. In the ED, investigations may be conducted to diagnose infection as the cause of the presenting illness, identify the source, distinguish sepsis from uncomplicated infection (i.e. without organ dysfunction) and/ or risk stratification. Appropriate sample collection for microbiological testing remains key for subsequent confirmation of diagnosis and rationalisation of antimicrobials. Routine laboratory investigations such as creatinine, bilirubin, platelet count and lactate are now critical elements in the diagnosis of sepsis and septic shock. With no biomarker sufficiently validated to rule out bacterial infection in the ED, there remains substantial interest in biomarkers representing various pathogenic pathways. New technologies for screening multiple genes and proteins are identifying unique network 'signatures' of clinical interest. Other future directions include rapid detection of bacterial DNA in blood, genes for antibiotic resistance and EMR-based computational biomarkers that collate multiple information sources. Reliable, cost-effective tests, validated in the ED to promptly and accurately identify sepsis, and to guide initial antibiotic choices, are important goals of current research efforts.-
dc.subjectdiagnostic techniques and procedures-
dc.subjectmass screening-
dc.subjectmonitoring physiologic-
dc.titleReview article: Sepsis in the emergency department - Part 2: Investigations and monitoring.-
dc.typeJournal Article-
dc.identifier.journaltitleEmergency Medicine Australasia : EMA-
dc.identifier.affiliationEmergency Department, Westmead Hospital, Sydney, New South Wales, Australia-
dc.identifier.affiliationWestmead Clinical School, The University of Sydney, Sydney, New South Wales, Australia-
dc.identifier.affiliationCentre for Clinical Research in Emergency Medicine, Harry Perkins Institute of Medical Research, Perth, Western Australia, Australia-
dc.identifier.affiliationDepartment of Emergency Medicine, Royal Perth Hospital, Perth, Western Australia, Australia-
dc.identifier.affiliationDivision of Emergency Medicine, The University of Western Australia, Perth, Western Australia, Australia-
dc.identifier.affiliationSchool of Medicine, Bond University, Gold Coast, Queensland, Australia-
dc.identifier.affiliationSchool of Medicine, Griffith University, Gold Coast, Queensland, Australia-
dc.identifier.affiliationDepartment of Emergency Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia-
dc.identifier.affiliationFaculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia-
dc.identifier.affiliationImmunology Department, Westmead Millennium Institute for Medical Research, Sydney, New South Wales, Australia-
dc.identifier.affiliationNepean Clinical School, The University of Sydney, Sydney, New South Wales, Australia-
dc.identifier.affiliationDepartment of Emergency Medicine, Leiden University Medical Centre, Leiden, The Netherlands-
dc.identifier.affiliationCritical Care and Trauma Division, George Institute for Global Health, Sydney, New South Wales, Australia-
dc.identifier.affiliationCritical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia-
dc.identifier.affiliationIntensive Care Unit, St Andrew's War Memorial Hospital, Brisbane, Queensland, Australia-
dc.identifier.affiliationDivision of Critical Care, George Institute for Global Health, Sydney, New South Wales, Australia-
dc.identifier.affiliationDepartment of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia-
dc.identifier.affiliationSchool of Medicine, The University of Melbourne, Melbourne, Victoria, Australia-
dc.identifier.affiliationInfectious Diseases, Westmead Hospital, Western Sydney Local Health District, Sydney, New South Wales, Australia-
dc.identifier.affiliationInstitute of Clinical Pathology and Medical Research, Pathology West, Sydney, New South Wales, Australia-
dc.type.austinJournal Article-
dc.type.austinReview-, Rinaldo
item.fulltextNo Fulltext-
item.openairetypeJournal Article- Care- Analytics Research and Evaluation (DARE) Centre-
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