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Title: EpCAM Immunotherapy versus Specific Targeted Delivery of Drugs.
Austin Authors: Macdonald, Joanna;Henri, Justin;Roy, Kislay;Hays, Emma;Bauer, Michelle;Veedu, Rakesh Naduvile;Pouliot, Normand;Shigdar, Sarah
Affiliation: School of Medicine, Deakin University, Geelong, VIC 3128, Australia
Centre for Comparative Genomics, Murdoch University, Perth, WA, Australia
Perron Institute for Neurological and Translational Science, Perth, WA, Australia
Department of Pathology and University of Melbourne, Melbourne, VIC , Australia
Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia
Matrix Microenvironment and Metastasis Laboratory, Olivia Newton-John Cancer Research Institute, School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia
Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia
Issue Date: Jan-2018
Date: 2018-01-12
Publication information: Cancers 2018; 10(1): e19
Abstract: The epithelial cell adhesion molecule (EpCAM), or CD326, was one of the first cancer associated biomarkers to be discovered. In the last forty years, this biomarker has been investigated for use in personalized cancer therapy, with the first monoclonal antibody, edrecolomab, being trialled in humans more than thirty years ago. Since then, several other monoclonal antibodies have been raised to EpCAM and tested in clinical trials. However, while monoclonal antibody therapy has been investigated against EpCAM for almost 40 years as primary or adjuvant therapy, it has not shown as much promise as initially heralded. In this review, we look at the reasons why and consider alternative targeting options, such as aptamers, to turn this almost ubiquitously expressed epithelial cancer biomarker into a viable target for future personalized therapy.
DOI: 10.3390/cancers10010019
Journal: Cancers
PubMed URL: 29329202
ISSN: 2072-6694
Type: Journal Article
Subjects: EpCAM
Appears in Collections:Journal articles

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