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Title: Canine Mixed Mammary Tumour as a Model for Human Breast Cancer with Osseous Metaplasia.
Austin Authors: Saad, E S;Milley, K M;Al-Khan, A A;Nimmo, J S;Bacci, B;Tayebi, M;Day, M J;Richardson, S J;Danks, J A
Affiliation: School of Veterinary Sciences, University of Bristol, Langford, UK
Department of Pathology, Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Werribee, Victoria, Australia
School of Veterinary Medicine, University of Surrey, Guildford, UK
The University of Melbourne, Department of Medicine, Austin Health, Heidelberg, Victoria, Australia
School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia
Australian Specialised Animal Pathology Laboratory, Mulgrave, Victoria, Australia
Issue Date: May-2017 2017
Publication information: Journal of comparative pathology 2017-05; 156(4): 352-365
Abstract: Canine mixed mammary tumours (CMMTs) and human metaplastic breast carcinomas (HMBCs) share several histopathological features and risk factors. In both species, these tumours display epithelial and stromal components. HMBCs are rare malignant tumours, but CMMTs are one of the most common mammary tumours in dogs and are more often benign than malignant. In this study, benign (n = 88) and malignant (n = 13) CMMTs were characterized using specific antibodies against oestrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, cytokeratin 5/6, cytokeratin AE1/AE3, vimentin, Ki67, E-cadherin and p63. Cartilage and bone matrices associated with benign and malignant CMMTs were characterized using specific antibodies against BMP4, Runx2, Sox9 and osteopontin. The current study suggested that CMMTs are of epithelial origin, but display a myoepithelial-like differentiation. The findings suggest key roles for Sox9, Runx2 and BMP4 in chondrogenesis and bone formation in CMMTs. The high expression of osteopontin in CMMTs appears to be unrelated to tumour malignancy.
DOI: 10.1016/j.jcpa.2017.03.005
Journal: Journal of comparative pathology
PubMed URL: 28449818
Type: Journal Article
Subjects: dog
human Breast cancer
mixed mammary tumour
Appears in Collections:Journal articles

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