Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/17237
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dc.contributor.authorElander, N O-
dc.contributor.authorAughton, K-
dc.contributor.authorGhaneh, P-
dc.contributor.authorNeoptolemos, J P-
dc.contributor.authorPalmer, D H-
dc.contributor.authorCox, T F-
dc.contributor.authorCampbell, F-
dc.contributor.authorCostello, E-
dc.contributor.authorHalloran, C M-
dc.contributor.authorMackey, J R-
dc.contributor.authorScarfe, A G-
dc.contributor.authorValle, J W-
dc.contributor.authorMcDonald, A C-
dc.contributor.authorCarter, R-
dc.contributor.authorTebbutt, Niall C-
dc.contributor.authorGoldstein, D-
dc.contributor.authorShannon, J-
dc.contributor.authorDervenis, C-
dc.contributor.authorGlimelius, B-
dc.contributor.authorDeakin, M-
dc.contributor.authorCharnley, R M-
dc.contributor.authorAnthoney, A-
dc.contributor.authorLerch, M M-
dc.contributor.authorMayerle, J-
dc.contributor.authorOláh, A-
dc.contributor.authorBüchler, M W-
dc.contributor.authorGreenhalf, W-
dc.date2018-03-09-
dc.date.accessioned2018-03-21T02:16:42Z-
dc.date.available2018-03-21T02:16:42Z-
dc.date.issued2018-
dc.identifier.citationBritish Journal of Cancer 2018; 118(8): 1084-1088-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/17237-
dc.description.abstractDeoxycytidylate deaminase (DCTD) and ribonucleotide reductase subunit M1 (RRM1) are potential prognostic and predictive biomarkers for pyrimidine-based chemotherapy in pancreatic adenocarcinoma. Immunohistochemical staining of DCTD and RRM1 was performed on tissue microarrays representing tumour samples from 303 patients in European Study Group for Pancreatic Cancer (ESPAC)-randomised adjuvant trials following pancreatic resection, 272 of whom had received gemcitabine or 5-fluorouracil with folinic acid in ESPAC-3(v2), and 31 patients from the combined ESPAC-3(v1) and ESPAC-1 post-operative pure observational groups. Neither log-rank testing on dichotomised strata or Cox proportional hazard regression showed any relationship of DCTD or RRM1 expression levels to survival overall or by treatment group. Expression of either DCTD or RRM1 was not prognostic or predictive in patients with pancreatic adenocarcinoma who had had post-operative chemotherapy with either gemcitabine or 5-fluorouracil with folinic acid.-
dc.language.isoeng-
dc.titleIntratumoural expression of deoxycytidylate deaminase or ribonuceotide reductase subunit M1 expression are not related to survival in patients with resected pancreatic cancer given adjuvant chemotherapy.-
dc.typeJournal Article-
dc.identifier.journaltitleBritish Journal of Cancer-
dc.identifier.affiliationCancer Research U.K. Liverpool Cancer Trials Unit, University of Liverpool, Liverpool, UK-
dc.identifier.affiliationCross Cancer Institute and University of Alberta, Edmonton, Canada-
dc.identifier.affiliationUniversity of Manchester/The Christie NHS Foundation Trust, Manchester, UK-
dc.identifier.affiliationThe Beatson West of Scotland Cancer Centre, Glasgow, UK-
dc.identifier.affiliationGlasgow Royal Infirmary, Glasgow, UK-
dc.identifier.affiliationAustin Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationPrince of Wales hospital and Clinical School, University of New South Wales, Sydney, NSW, Australia-
dc.identifier.affiliationNepean Cancer Centre and University of Sydney, Camperdown, NSW, Australia-
dc.identifier.affiliationThe Agia Olga Hospital, Athens, Greece-
dc.identifier.affiliationDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden-
dc.identifier.affiliationUniversity Hospital, North Staffordshire, Staffordshire, UK-
dc.identifier.affiliationFreeman Hospital, Newcastle upon Tyne, UK-
dc.identifier.affiliationSt James's University Hospital, Leeds, UK-
dc.identifier.affiliationDepartment of Medicine A, University Medicine Greifswald, Greifswald, Germany-
dc.identifier.affiliationDepartment of Medicine II, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany-
dc.identifier.affiliationThe Petz Aladar Hospital, Gyor, Hungary-
dc.identifier.affiliationDepartment of Surgery, University of Heidelberg, Heidelberg, Germany-
dc.identifier.doi10.1038/s41416-018-0005-1-
dc.identifier.orcid0000-0002-1999-0863-
dc.identifier.pubmedid29523831-
dc.type.austinJournal Article-
local.name.researcherTebbutt, Niall C
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
crisitem.author.deptMedical Oncology-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
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