Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/17002
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dc.contributor.authorLalic, Samanta-
dc.contributor.authorSluggett, Janet K-
dc.contributor.authorIlomäki, Jenni-
dc.contributor.authorWimmer, Barbara C-
dc.contributor.authorTan, Edwin CK-
dc.contributor.authorRobson, Leonie-
dc.contributor.authorEmery, Tina-
dc.contributor.authorBell, J Simon-
dc.date.accessioned2017-12-08T03:22:02Z-
dc.date.available2017-12-08T03:22:02Z-
dc.date.issued2016-11-01-
dc.identifier.citationJournal of the American Medical Directors Association 2016; 17(11): 1067.e1-1067.e6en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/17002-
dc.description.abstractOBJECTIVES: To investigate the association between polypharmacy and medication regimen complexity with time to first hospitalization, number of hospitalizations, and number of hospital days over a 12-month period. DESIGN: A 12-month prospective cohort study. PARTICIPANTS AND SETTING: A total of 383 residents of 6 Australian long-term care facilities (LTCFs). MEASUREMENTS: The primary exposures were polypharmacy (≥9 regular medications) and the 65-item Medication Regimen Complexity Index (MRCI). Cox proportional hazards regression was used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between polypharmacy and MRCI with time to first hospitalization. Poisson regression was used to compute incident rate ratios (IRR) and 95% CIs for the association between polypharmacy and MRCI with number of hospitalizations and number of hospital days. Models were adjusted for age, sex, length of stay in LTCF, comorbidities, activities of daily living, and dementia severity. RESULTS: There were 0.56 (95% CI 0.49-0.65) hospitalizations per person-year and 4.52 (95% CI 4.31-4.76) hospital days per person-year. In adjusted analyses, polypharmacy was associated with time to first hospitalization (HR 1.84; 95% CI 1.21-2.79), number of hospitalizations (IRR 1.51; 95% CI 1.09-2.10), and hospital days per person-year (IRR 1.39; 95% CI 1.24-1.56). Similarly, in adjusted analyses a 10-unit increase in MRCI was associated with time to first hospitalization (HR 1.17; 95% CI 1.06-1.29), number of hospitalizations (IRR 1.15; 95% CI 1.06-1.24), and hospital days per person-year (IRR 1.19; 95% CI 1.16-1.23). CONCLUSIONS: Polypharmacy and medication regimen complexity are associated with hospitalizations from LTCFs. This highlights the importance of regular medication review for residents of LTCFs and the need for further research into the risk-to-benefit ratio of prescribing in this setting.en_US
dc.subjectPolypharmacyen_US
dc.subjecthospitalizationen_US
dc.subjectlong-term careen_US
dc.subjectmedication regimen complexityen_US
dc.subjectnursing homesen_US
dc.titlePolypharmacy and medication regimen complexity as risk factors for hospitalization among residents of long-term care facilities: a prospective cohort studyen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of the American Medical Directors Associationen_US
dc.identifier.affiliationCentre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australiaen_US
dc.identifier.affiliationPharmacy Department, Austin Health, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationNHMRC Cognitive Decline Partnership Center, Hornsby Ku-ring-gai Hospital, Hornsby, New South Wales, Australiaen_US
dc.identifier.affiliationSchool of Public Health and Preventative Medicine, Monash University, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDivision of Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australiaen_US
dc.identifier.affiliationAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Swedenen_US
dc.identifier.affiliationResthaven Incorporated, Adelaide, South Australia, Australiaen_US
dc.identifier.affiliationSansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/27780570en_US
dc.identifier.doi10.1016/j.jamda.2016.08.019en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
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