Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16779
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dc.contributor.authorDowney, Luke A-
dc.contributor.authorTysse, Brenda-
dc.contributor.authorFord, Talitha C-
dc.contributor.authorSamuels, Angela C-
dc.contributor.authorWilson, Rory P-
dc.contributor.authorParrott, Andrew C-
dc.date.accessioned2017-08-10T01:08:15Z-
dc.date.available2017-08-10T01:08:15Z-
dc.date.issued2017-04-19-
dc.identifier.citationJournal of Clinical Pharmacology 2017; online first: 19 Aprilen_US
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/16779-
dc.description.abstractThe recreational use of various stimulant drugs has been implicated in the development of movement disorders through dysregulation of the dopaminergic and serotoninergic neurotransmitter systems. The present study investigated psychomotor differences in current and former recreational stimulant drug users compared with nonusing controls. Sixty participants comprised 3 groups: 20 current stimulant drug users (CSUs; 11 men, aged 31.4 ± 9.1 years), 20 former stimulant drug users (FSUs; 5 men, aged 39.1 ± 8.5 years), and 20 nonuser controls (NUCs; 5 men, aged 35.7 ± 6.4 years). Psychomotor arm steadiness for each participant was assessed with a wrist-attached accelerometer during 5 arm positions with eyes open and then eyes closed. Arm-drop of arm position was indicated by the arm longitudinal rotation axis (ALoRA), and tremor was indicated by the overall vector of dynamic body acceleration (VeDBA). Overall, CSUs performed the most poorly on ALoRA (P < .05) and VeDBA indices (P < .05), and FSUs perform almost as poorly on VeDBA indices (P < .05) compared with NUCs. It was concluded that stimulant drug use, primarily MDMA and amphetamines, may result in acute stimulant-induced tremor as well as long-term proprioceptive deficits in terms of arm-droop.en_US
dc.subjectMDMAen_US
dc.subjectAbstinenceen_US
dc.subjectAccelerometryen_US
dc.subjectAmphetamineen_US
dc.subjectEcstasyen_US
dc.subjectPsychomotoren_US
dc.subjectTremoren_US
dc.titlePsychomotor tremor and proprioceptive control problems in current and former stimulant drug users: an accelerometer study of heavy users of amphetamine, mdma, and other recreational stimulantsen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Clinical Pharmacologyen_US
dc.identifier.affiliationInstitute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationCentre for Human Psychopharmacology, Swinburne University, Hawthorn, Melbourne, Australiaen_US
dc.identifier.affiliationDepartment of Biosciences, College of Science, Swansea University, Singleton Park, Swansea, Wales, UKen_US
dc.identifier.affiliationDepartment of Psychology, College of Human and Health Sciences, Swansea University, Singleton Park, Swansea, Wales, UKen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/28425095en_US
dc.identifier.doi10.1002/jcph.925en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
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