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dc.contributor.authorFairley, Jessica L-
dc.contributor.authorZhang, Ling-
dc.contributor.authorGlassford, Neil J-
dc.contributor.authorBellomo, Rinaldo-
dc.identifier.citationJournal of Critical Care 2017; 42: 69-77en_US
dc.description.abstractPURPOSE: To investigate magnesium as prophylaxis or treatment of postoperative arrhythmias in cardiac surgery (CS) patients. To assess impact on biochemical and patient-centered outcomes. MATERIALS AND METHODS: We searched MEDLINE, CENTRAL and EMBASE electronic databases from 1975 to October 2015 using terms related to magnesium and CS. English-Language RCTs were included involving adults undergoing CS with parenterally administered magnesium to treat or prevent arrhythmias, compared to control or standard antiarrythmics. We extracted incidence of postoperative arrhythmias, termination following magnesium administration and secondary outcomes (including mortality, length of stay, hemodynamic parameters, biochemistry). RESULTS: Thirty-five studies were included, with significant methodological heterogeneity. Atrial fibrillation (AF) was most commonly reported, followed by ventricular, supraventricular and overall arrhythmia frequency. Magnesium appeared to reduce AF (RR 0.69, 95% confidence interval (95%CI) 0.56-0.86, p=0.002), particularly postoperatively (RR 0.51, 95%CI 0.34-0.77, p=0.003) for longer than 24h. Maximal benefit was seen with bolus doses up to 60mmol. Magnesium appeared to reduce ventricular arrhythmias (RR=0.46, 95%CI 0.24-0.89, p=0.004), with a trend to reduced overall arrhythmias (RR=0.80, 95%CI 0.57-1.12, p=0.191). We found no mortality effect or significant increase in adverse events. CONCLUSIONS: Magnesium administration post-CS appears to reduce AF without significant adverse events. There is limited evidence to support magnesium administration for prevention of other arrhythmias.en_US
dc.subjectBiochemical outcomeen_US
dc.subjectCritical illnessen_US
dc.subjectElectrolyte disturbanceen_US
dc.subjectIntensive careen_US
dc.subjectMagnesium administrationen_US
dc.subjectMagnesium therapyen_US
dc.subjectPatient-centered outcomeen_US
dc.titleMagnesium status and magnesium therapy in cardiac surgery: a systematic review and meta-analysis focusing on arrhythmia preventionen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Critical Careen_US
dc.identifier.affiliationAlfred Hospital, Prahran, Victoria, Australiaen_US
dc.identifier.affiliationSchool of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, Chinaen_US
dc.type.austinJournal Articleen_US
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristype Care- Analytics Research and Evaluation (DARE) Centre-
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