Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKüpper, Hanna-
dc.contributor.authorKudernatsch, Manfred-
dc.contributor.authorPieper, Tom-
dc.contributor.authorGroeschel, Samuel-
dc.contributor.authorTournier, Jacques-Donald-
dc.contributor.authorRaffelt, David-
dc.contributor.authorWinkler, Peter-
dc.contributor.authorHolthausen, Hans-
dc.contributor.authorStaudt, Martin-
dc.identifier.citationBrain 2016; 139(9): 2456-2468en_US
dc.description.abstractHemidisconnections (i.e. hemispherectomies or hemispherotomies) invariably lead to contralateral hemiparesis. Many patients with a pre-existing hemiparesis, however, experience no deterioration in motor functions, and some can still grasp with their paretic hand after hemidisconnection. The scope of our study was to predict this phenomenon. Hypothesizing that preserved contralateral grasping ability after hemidisconnection can only occur in patients controlling their paretic hands via ipsilateral corticospinal projections already in the preoperative situation, we analysed the asymmetries of the brainstem (by manual magnetic resonance imaging volumetry) and of the structural connectivity of the corticospinal tracts within the brainstem (by magnetic resonance imaging diffusion tractography), assuming that marked hypoplasia or Wallerian degeneration on the lesioned side in patients who can grasp with their paretic hands indicate ipsilateral control. One hundred and two patients who underwent hemidisconnections between 0.8 and 36 years of age were included. Before the operation, contralateral hand function was normal in 3/102 patients, 47/102 patients showed hemiparetic grasping ability and 52/102 patients could not grasp with their paretic hands. After hemidisconnection, 20/102 patients showed a preserved grasping ability, and 5/102 patients began to grasp with their paretic hands only after the operation. All these 25 patients suffered from pre- or perinatal brain lesions. Thirty of 102 patients lost their grasping ability. This group included all seven patients with a post-neonatally acquired or progressive brain lesion who could grasp before the operation, and also all three patients with a preoperatively normal hand function. The remaining 52/102 patients were unable to grasp pre- and postoperatively. On magnetic resonance imaging, the patients with preserved grasping showed significantly more asymmetric brainstem volumes than the patients who lost their grasping ability. Similarly, these patients showed striking asymmetries in the structural connectivity of the corticospinal tracts. In summary, normal preoperative hand function and a post-neonatally acquired or progressive lesion predict a loss of grasping ability after hemidisconnection. A postoperatively preserved grasping ability is possible in hemiparetic patients with pre- or perinatal lesions, and this is highly likely when the brainstem is asymmetric and especially when the structural connectivity of the corticospinal tracts within the brainstem is asymmetric.en_US
dc.subjectCongenital hemiparesisen_US
dc.subjectDiffusion-weighted MRI tractographyen_US
dc.subjectIpsilateral (re)organizationen_US
dc.titlePredicting hand function after hemidisconnectionen_US
dc.typeJournal Articleen_US
dc.identifier.affiliationDepartment of Paediatric Neurology and Developmental Medicine, Children's Hospital, University of Tübingen, Germanyen_US
dc.identifier.affiliationNeurosurgery Clinic and Clinic for Epilepsy Surgery, Schön Klinik Vogtareuth, Germanyen_US
dc.identifier.affiliationClinic for Neuropaediatrics and Neurorehabilitation, Epilepsy Centre for Children and Adolescents, Schön Klinik, Vogtareuth, Germanyen_US
dc.identifier.affiliationBiomedical Engineering Department, King's College London, UKen_US
dc.identifier.affiliationFlorey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australiaen_US
dc.type.austinJournal Articleen_US
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
Appears in Collections:Journal articles
Show simple item record

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.