Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16685
Full metadata record
DC FieldValueLanguage
dc.contributor.authorWerden, Emilio-
dc.contributor.authorCumming, Toby-
dc.contributor.authorLi, Qi-
dc.contributor.authorBird, Laura-
dc.contributor.authorVeldsman, Michele-
dc.contributor.authorPardoe, Heath R-
dc.contributor.authorJackson, Graeme D-
dc.contributor.authorDonnan, Geoffrey A-
dc.contributor.authorBrodtmann, Amy-
dc.date2017-06-09-
dc.date.accessioned2017-06-25T23:53:57Z-
dc.date.available2017-06-25T23:53:57Z-
dc.date.issued2017-07-
dc.identifier.citationNeurology 2017; 89(2): 116-124en_US
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/16685-
dc.description.abstractOBJECTIVE: To examine associations between ischemic stroke, vascular risk factors, and MRI markers of brain aging. METHODS: Eighty-one patients (mean age 67.5 ± 13.1 years, 31 left-sided, 61 men) with confirmed first-ever (n = 66) or recurrent (n = 15) ischemic stroke underwent 3T MRI scanning within 6 weeks of symptom onset (mean 26 ± 9 days). Age-matched controls (n = 40) completed identical testing. Multivariate regression analyses examined associations between group membership and MRI markers of brain aging (cortical thickness, total brain volume, white matter hyperintensity [WMH] volume, hippocampal volume), normalized against intracranial volume, and the effects of vascular risk factors on these relationships. RESULTS: First-ever stroke was associated with smaller hippocampal volume (p = 0.025) and greater WMH volume (p = 0.004) relative to controls. Recurrent stroke was in turn associated with smaller hippocampal volume relative to both first-ever stroke (p = 0.017) and controls (p = 0.001). These associations remained significant after adjustment for age, sex, education, and, in stroke patients, infarct volume. Total brain volume was not significantly smaller in first-ever stroke patients than in controls (p = 0.056), but the association became significant after further adjustment for atrial fibrillation (p = 0.036). Cortical thickness and brain volumes did not differ as a function of stroke type, infarct volume, or etiology. CONCLUSIONS: Brain structure is likely to be compromised before ischemic stroke by vascular risk factors. Smaller hippocampal and total brain volumes and increased WMH load represent proxies for underlying vascular brain injury.en_US
dc.titleStructural MRI markers of brain aging early after ischemic strokeen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleNeurologyen_US
dc.identifier.affiliationFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationAustin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationEastern Clinical Research Unit, Monash University, Box Hill Hospital, Melbourne, Victoria, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/28600458en_US
dc.identifier.doi10.1212/WNL.0000000000004086en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
Appears in Collections:Journal articles
Show simple item record

Page view(s)

16
checked on Jul 2, 2021

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.