Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16681
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dc.contributor.authorSeah, Dean-
dc.contributor.authorChoy, Matthew C-
dc.contributor.authorGorelik, Alexandra-
dc.contributor.authorConnell, William R-
dc.contributor.authorSparrow, Miles P-
dc.contributor.authorvan Langenberg, Daniel-
dc.contributor.authorHebbard, Geoffrey-
dc.contributor.authorMoore, Gregory-
dc.contributor.authorDe Cruz, Peter-
dc.date.accessioned2017-06-25T23:50:26Z-
dc.date.available2017-06-25T23:50:26Z-
dc.date.issued2018-01-
dc.identifier.citationJournal of Gastroenterology and Hepatology 2018; 33(1): 226-231en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16681-
dc.description.abstractBACKGROUND AND AIMS: Data supporting the optimal maintenance drug therapy & strategy to monitor ongoing response following successful infliximab (IFX) induction, for acute severe ulcerative colitis (ASUC), are limited. We aimed to evaluate maintenance & monitoring strategies employed in patients post IFX induction therapy. METHODS: Patients in 6 Australian tertiary centres treated with IFX for steroid-refractory ASUC between April 2014 & May 2015 were identified via hospital IBD & pharmacy databases. Patients were followed-up for 1 year with clinical data over 12 months recorded. Analysis was limited to patient outcomes beyond 3 months. RESULTS: 41 patients were identified. 5/41 (12%) patients underwent colectomy within 3 months and 1 patient was lost to follow-up. 6/35 (17%) of the remaining patients progressed to colectomy by 12 months. MAINTENANCE THERAPY: Patients maintained on thiopurine monotherapy (14/35) vs. IFX/thiopurine therapy (15/35) were followed up. 2/15 (13%) patients who received combination maintenance therapy underwent a colectomy at 12 months, compared with 1/14 (7%) patients receiving thiopurine monotherapy (p=0.610). MONITORING DURING MAINTENANCE: Post-discharge, thiopurine metabolites were monitored in 15/27 (56%); faecal calprotectin in 11/32 (34%); & serum IFX levels in 4/20 (20%). 20/32 (63%) patients had an endoscopic evaluation after IFX salvage with median time to 1st endoscopy of 109 days (IQR 113-230). CONCLUSION: Following IFX induction therapy for ASUC, the uptake of maintenance therapy in this cohort & strategies to monitor ongoing response were variable. These data suggest that the optimal maintenance & monitoring strategy post IFX salvage therapy remains to be defined.en_US
dc.subjectAcute Severe Ulcerative Colitisen_US
dc.subjectInfliximaben_US
dc.subjectMaintenance Therapyen_US
dc.subjectMonitoringen_US
dc.subjectThiopurineen_US
dc.titleExamining maintenance care following infliximab salvage therapy for acute severe ulcerative colitisen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Gastroenterology and Hepatologyen_US
dc.identifier.affiliationGastroenterology and Hepatologyen_US
dc.identifier.affiliationDepartment of Medicine, Austin Academic Centre, University of Melbourne, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationMelbourne EpiCentre, Melbourne Health, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Gastroenterology, Alfred Health, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Medicine, Monash University, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Gastroenterology, Eastern Health, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Gastroenterology, Melbourne Health, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Gastroenterology, Monash Health, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/28618062en_US
dc.identifier.doi10.1111/jgh.13850en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
local.name.researcherChoy, Matthew C
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptGastroenterology and Hepatology-
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