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dc.contributor.authorPedersen, Mangor-
dc.contributor.authorOmidvarnia, Amir-
dc.contributor.authorCurwood, Evan K-
dc.contributor.authorWalz, Jennifer M-
dc.contributor.authorRayner, Genevieve-
dc.contributor.authorJackson, Graeme D-
dc.identifier.citationNeuroImage: Clinical 2017; 15: 209-214en_US
dc.description.abstractFocal epilepsy is characterised by paroxysmal events, reflecting changes in underlying local brain networks. To capture brain network activity at the maximal temporal resolution of the acquired functional magnetic resonance imaging (fMRI) data, we have previously developed a novel analysis framework called Dynamic Regional Phase Synchrony (DRePS). DRePS measures instantaneous mean phase coherence within neighbourhoods of brain voxels. We use it here to examine how the dynamics of the functional connections of regional brain networks are altered in neocortical focal epilepsy. Using task-free fMRI data from 21 subjects with focal epilepsy and 21 healthy controls, we calculated the power spectral density of DRePS, which is a measure of signal variability in local connectivity estimates. Whole-brain averaged power spectral density of DRePS, or signal variability of local connectivity, was significantly higher in epilepsy subjects compared to healthy controls. Maximal increase in DRePS spectral power was seen in bilateral inferior frontal cortices, ipsilateral mid-cingulate gyrus, superior temporal gyrus, caudate head, and contralateral cerebellum. Our results provide further evidence of common brain abnormalities across people with focal epilepsy. We postulate that dynamic changes in specific cortical brain areas may help maintain brain function in the presence of pathological epileptiform network activity in neocortical focal epilepsy.en_US
dc.subjectDynamic connectivityen_US
dc.subjectFocal epilepsyen_US
dc.subjectInstantaneous phase synchronyen_US
dc.titleThe dynamics of functional connectivity in neocortical focal epilepsyen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleNeuroImage: Clinicalen_US
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health and The University of Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationMelbourne School of Psychological Sciences, The University of Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Neurology, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.type.austinJournal Articleen_US
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristype Florey Institute of Neuroscience and Mental Health- Florey Institute of Neuroscience and Mental Health-
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