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dc.contributor.authorWalz, Jennifer M-
dc.contributor.authorPedersen, Mangor-
dc.contributor.authorOmidvarnia, Amir-
dc.contributor.authorSemmelroch, Mira-
dc.contributor.authorJackson, Graeme D-
dc.identifier.citationBrain 2017; 140(4): 998-1010en_US
dc.description.abstractEpileptic spikes occur on the sub-second timescale and are known to involve not only epileptic foci but also large-scale distributed brain networks. There is likely to be a sequence of neural activity in multiple brain regions that occurs within the duration of a single spike, but standard electroencephalography-functional magnetic resonance imaging analyses, which use only the timing of the spikes to model the functional magnetic resonance imaging data, cannot determine the sequence of these activations. Our aim in this study is to temporally resolve these spatial activations to observe the spatiotemporal dynamics of the spike-related neural activity at a sub-second timescale. We studied eight focal epilepsy patients (age 11-42 years, six female) and used amplitude features of the electroencephalogram specific to different spike components (early and late peaks and troughs) to encode temporal information into our functional magnetic resonance imaging models. This enables us to associate each activation with a specific model of each of the spike components to infer the temporal order of these spike-related spatial activations. In seven of eight patients the distributed networks were associated with the late spike component. The focal activations were more variably coupled with time epochs, but tended to precede the distributed network effects. We also found that incorporating electroencephalogram features into the models increased sensitivity and in six patients revealed additional regions unseen in the standard analysis result. This included strong bilateral thalamus activation in two patients. We demonstrate the clinical utility of this approach in a patient who recently underwent a successful surgical resection of the region where we saw enhanced activation using electroencephalogram amplitude information specific to the early spike component. This focal cluster of activation was larger and more precisely tracked the anatomy compared to what was seen using the standard timing-based analysis. Our novel electroencephalography-functional magnetic resonance imaging data fusion approach, which utilizes information based on the single spike variability across all electroencephalogram channels, has the potential to help us better understand epileptic networks and aid in the interpretation of functional magnetic resonance imaging activation maps during treatment planning.en_US
dc.subjectAmplitude variabilityen_US
dc.subjectFocal epilepsyen_US
dc.subjectFunctional MRIen_US
dc.titleSpatiotemporal mapping of epileptic spikes using simultaneous EEG-functional MRIen_US
dc.typeJournal Articleen_US
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, Austin Campus, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationThe Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australiaen_US
dc.identifier.affiliationDepartment of Neurology, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.type.austinJournal Articleen_US
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristype Florey Institute of Neuroscience and Mental Health-
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