Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16530
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dc.contributor.authorHuo, Cecilia W-
dc.contributor.authorWaltham, Mark-
dc.contributor.authorKhoo, Christine-
dc.contributor.authorFox, Stephen B-
dc.contributor.authorHill, Prue-
dc.contributor.authorChen, Shou-
dc.contributor.authorChew, Grace L-
dc.contributor.authorPrice, John T-
dc.contributor.authorNguyen, Chau H-
dc.contributor.authorWilliams, Elizabeth D-
dc.contributor.authorHenderson, Michael-
dc.contributor.authorThompson, Erik W-
dc.contributor.authorBritt, Kara L-
dc.date.accessioned2017-01-18T07:26:33Z-
dc.date.available2017-01-18T07:26:33Z-
dc.date.issued2016-10-25-
dc.identifier.citationBreast Cancer Research 2016; 18(1): 106en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16530-
dc.description.abstractBACKGROUND: High mammographic density (HMD) not only confers a significantly increased risk of breast cancer (BC) but also is associated with BCs of more advanced stages. However, it is unclear whether BC progression and metastasis are stimulated by HMD. We investigated whether patient-derived HMD breast tissue could stimulate the progression of MCF10DCIS.com cells compared with patient-matched low mammographic density (LMD) tissue. METHODS: Sterile breast specimens were obtained immediately after prophylactic mastectomy from high-risk women (nā€‰=ā€‰10). HMD and LMD regions of each specimen were resected under radiological guidance. Human MCF10DCIS.com cells, a model of ductal carcinoma in situ (DCIS), were implanted into silicone biochambers in the groins of severe combined immunodeficiency mice, either alone or with matched LMD or HMD tissue (1:1), and maintained for 6 weeks. We assessed biochamber weight as a measure of primary tumour growth, histological grade of the biochamber material, circulating tumour cells and metastatic burden by luciferase and histology. All statistical tests were two-sided. RESULTS: HMD breast tissue led to increased primary tumour take, increased biochamber weight and increased proportions of high-grade DCIS and grade 3 invasive BCs compared with LMD. This correlated with an increased metastatic burden in the mice co-implanted with HMD tissue. CONCLUSIONS: Our study is the first to explore the direct effect of HMD and LMD human breast tissue on the progression and dissemination of BC cells in vivo. The results suggest that HMD status should be a consideration in decision-making for management of patients with DCIS lesions.en_US
dc.subjectBreast canceren_US
dc.subjectMCF10DCIS.comen_US
dc.subjectMammographic densityen_US
dc.subjectMurine biochamberen_US
dc.titleMammographically dense human breast tissue stimulates MCF10DCIS.com progression to invasive lesions and metastasisen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleBreast Cancer Researchen_US
dc.identifier.affiliationAustin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Surgery, University of Melbourne, St Vincent's Hospital, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationSt Vincent's Institute of Medical Research, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Pathology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Pathology, University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationSir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Pathology, St Vincent's Hospital, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationNorthern Health, Epping, Victoria, Australiaen_US
dc.identifier.affiliationCollege of Health and Biomedicine, Victoria University, St Albans, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australiaen_US
dc.identifier.affiliationAustralian Institute for Musculoskeletal Science (AIMSS), Victoria University, University of Melbourne and Western Health, Sunshine Hospital, St Albans, Victoria, Australiaen_US
dc.identifier.affiliationInstitute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australiaen_US
dc.identifier.affiliationTranslational Research Institute, Woolloongabba, Queensland, Australiaen_US
dc.identifier.affiliationAustralian Prostate Cancer Centre - Queensland, Brisbane, Queensland, Australiaen_US
dc.identifier.affiliationDivision of Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationMetastasis Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/27776557en_US
dc.identifier.doi10.1186/s13058-016-0767-4en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
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