Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16482
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dc.contributor.authorPedersen, Mangor-
dc.contributor.authorCurwood, Evan K-
dc.contributor.authorVaughan, David N-
dc.contributor.authorOmidvarnia, Amir H-
dc.contributor.authorJackson, Graeme D-
dc.date2016-01-07-
dc.date.accessioned2017-01-06T02:37:44Z-
dc.date.available2017-01-06T02:37:44Z-
dc.date.issued2016-03-31-
dc.identifier.citationBrain Connectivity 2016; 6(3): 208-215en_US
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/16482-
dc.description.abstractIndividuals with focal epilepsy have heterogeneous sites of seizure origin. However, there may be brain regions that are common to most cases of intractable focal epilepsy. In this study, we aim to identify these using multivariate analysis of task-free functional MRI. Fourteen subjects with extratemporal focal epilepsy and 14 healthy controls were included in the study. Task-free functional MRI data were used to calculate voxel-wise regional connectivity with regional homogeneity (ReHo) and weighted degree centrality (DCw), in addition to regional activity using fraction of amplitude of low-frequency fluctuations (fALFF). Multivariate pattern analysis was applied to each of these metrics to discriminate brain areas that differed between focal epilepsy subjects and healthy controls. ReHo and DCw classified focal epilepsy subjects from healthy controls with high accuracy (89.3% and 75%, respectively). However, fALFF did not significantly classify patients from controls. Increased regional network activity in epilepsy subjects was seen in the ipsilateral piriform cortex, insula, and thalamus, in addition to the dorsal anterior cingulate cortex and lateral frontal cortices. Decreased regional connectivity was observed in the ventromedial prefrontal cortex, as well as lateral temporal cortices. Patients with extratemporal focal epilepsy have common areas of abnormality (ReHo and DCw measures), including the ipsilateral piriform cortex, temporal neocortex, and ventromedial prefrontal cortex. ReHo shows additional increase in the "salience network" that includes anterior insula and anterior cingulate cortex. DCw showed additional effects in the ipsilateral thalamus and striatum. These brain areas may represent key regional network properties underlying focal epilepsy.en_US
dc.subjectConnectomicsen_US
dc.subjectExtratemporalen_US
dc.subjectFocal epilepsyen_US
dc.subjectFunctional connectivityen_US
dc.subjectFunctional Magnetic Resonance Imagingen_US
dc.subjectMultivariate pattern analysisen_US
dc.titleAbnormal brain areas common to the focal epilepsies: multivariate pattern analysis of fMRIen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleBrain Connectivityen_US
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, Austin Campus, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationThe University of Melbourne, Florey Department of Neuroscience and Mental Health, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Neurology, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/26537783en_US
dc.identifier.doi10.1089/brain.2015.0367en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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