Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/16442Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Soliman, Caroline | - |
| dc.contributor.author | Yuriev, Elizabeth | - |
| dc.contributor.author | Ramsland, Paul A | - |
| dc.date | 2016-11-04 | - |
| dc.date.accessioned | 2016-11-23T01:06:40Z | - |
| dc.date.available | 2016-11-23T01:06:40Z | - |
| dc.date.issued | 2017-06 | - |
| dc.identifier.citation | Current Opinion in Structural Biology 2017; 44: 1-8 | en_US |
| dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/16442 | - |
| dc.description.abstract | Carbohydrate-binding antibodies and carbohydrate-based vaccines are being actively pursued as targeted immunotherapies for a broad range of cancers. Recognition of tumor-associated carbohydrates (glycans) by antibodies is predominantly towards terminal epitopes on glycoproteins and glycolipids on the surface of cancer cells. Crystallography along with complementary experimental and computational methods have been extensively used to dissect antibody recognition of glycan epitopes commonly found in cancer. We provide an overview of the structural biology of antibody recognition of tumor-associated glycans and propose potential rearrangements of these targets in the membrane that could dictate the complex biological activities of these antibodies against cancer cells. | en_US |
| dc.title | Antibody recognition of aberrant glycosylation on the surface of cancer cells | en_US |
| dc.type | Journal Article | en_US |
| dc.identifier.journaltitle | Current Opinion in Structural Biology | en_US |
| dc.identifier.affiliation | School of Science, RMIT University, Bundoora, Victoria, Australia | en_US |
| dc.identifier.affiliation | Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia | en_US |
| dc.identifier.affiliation | Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia | en_US |
| dc.identifier.affiliation | Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia | en_US |
| dc.identifier.affiliation | Centre for Biomedical Research, Burnet Institute, Melbourne, Victoria, Australia | en_US |
| dc.identifier.pubmeduri | https://pubmed.ncbi.nlm.nih.gov/27821276 | en_US |
| dc.identifier.doi | 10.1016/j.sbi.2016.10.009 | en_US |
| dc.type.content | Text | en_US |
| dc.type.austin | Journal Article | en_US |
| local.name.researcher | Ramsland, Paul A | |
| item.fulltext | No Fulltext | - |
| item.grantfulltext | none | - |
| item.openairetype | Journal Article | - |
| item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
| item.cerifentitytype | Publications | - |
| crisitem.author.dept | Surgery (University of Melbourne) | - |
| Appears in Collections: | Journal articles | |
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