Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16358
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dc.contributor.authorMalpas, Charles B-
dc.contributor.authorSaling, Michael M-
dc.contributor.authorVelakoulis, Dennis-
dc.contributor.authorDesmond, Patricia M-
dc.contributor.authorO’Brien, Terence J-
dc.date2015-05-12-
dc.date.accessioned2016-10-17T00:07:33Z-
dc.date.available2016-10-17T00:07:33Z-
dc.date.issued2015-
dc.identifier.citationJournal of Alzheimer's Disease 2015; 47(4): 965-975en_US
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/16358-
dc.description.abstractAlzheimer's disease (AD) is characterized by two primary pathologies: tau-related neurofibrillary tangles and the extracellular accumulation of amyloid-β (Aβ). The development of these pathologies is topologically distinct early in the disease, with Aβ beginning to accumulate as a diffuse, neocortical pathology, while tau-related pathology begins to form in mesial temporal regions. This study investigated the hypothesis that, by virtue of this distinction, there exist preferential associations between the primary pathologies and aspects of the cognitive phenotype. We investigated the relationship between cerebrospinal fluid (CSF) biomarkers for tau and Aβ pathologies with neurocognitive measures in 191 patients with mild cognitive impairment (MCI). Participants completed cognitive tests of new learning, information processing speed, and working memory. Separate regression models were computed and then followed up with mediation analyses to examine the predictive status of CSF biomarkers. The effect of Aβ on learning was mediated by phospho-tau (p = 0.008). In contrast, Aβ had a direct effect on information processing speed that was not mediated by phospho-tau (p = 0.59). No predictors were significant for working memory. This study provided evidence for a differential relationship of Aβ and phospho-tau pathologies on the neurocognitive phenotype of MCI. This supports the proposition that these primary AD pathologies maximally affect different aspects of cognition, and has potential implications for cognitive assessments and the use of biomarkers in disease-modifyingtherapeutic trials.en_US
dc.subjectAmyloid-βen_US
dc.subjectCerebrospinal fluiden_US
dc.subjectCognitionen_US
dc.subjectMild cognitive impairmenten_US
dc.subjectTauen_US
dc.titleTau and Amyloid-β cerebrospinal fluid biomarkers have differential relationships with cognition in mild cognitive impairmenten_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Alzheimer's Diseaseen_US
dc.identifier.affiliationMelbourne Brain Centre, Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationMelbourne School of Psychological Sciences, the University of Melbourne, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Neuropsychology, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationFlorey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationMelbourne Neuropsychiatry Centre, Royal Melbourne Hospital, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Psychiatry, University of Melbourne, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Radiology, University of Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Medical Imaging, Royal Melbourne Hospital, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Neurology, Royal Melbourne Hospital, Parkville, Victoria, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/26401775en_US
dc.identifier.doi10.3233/JAD-142643en_US
dc.contributor.corpauthorAlzheimer's Disease Neuroimaging Initiative-
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairetypeJournal Article-
crisitem.author.deptClinical Neuropsychology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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