Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16351
Title: Application of an epitope-based allocation system in pediatric kidney transplantation
Austin Authors: Kausman, Joshua Y;Walker, Amanda M;Cantwell, Linda S;Quinlan, Catherine;Sypek, Matthew P;Ierino, Francesco L
Affiliation: Department of Nephrology, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
Murdoch Childrens Research Institute, Melbourne, Victoria, Australia
University of Melbourne, Melbourne, Victoria, Australia
Victorian Immunogenetics and Transplantation Service, Australian Red Cross Blood Service, Melbourne, Victoria, Australia
Department of Nephrology, Austin Health, Heidelberg, Victoria, Australia
Issue Date: Nov-2016
metadata.dc.date: 2016-09-24
Publication information: Pediatric Transplantation 2016; 20(7): 931-938
Abstract: Donor-recipient HLA mismatch remains a leading cause for sensitization and graft loss in kidney transplantation. HLA compatibility at an epitope level is emerging as an improved method of matching compared with current HLA antigen allocation. A novel epitope-based allocation approach to prospectively exclude donors with high-level mismatches was implemented for pediatric KTRs on the DD waiting list. Nineteen consecutive transplants were followed for 12 months, including eight DD KTRs listed with eplet exclusions, as well as three DD KTRs and eight LD KTRs without exclusions. KTRs with eplet exclusions had estimated GFR of 78.5 mL/min/1.73 m2 , no episodes of rejection, and time to transplant 6.55 months. HLA-A, HLA-B, HLA-DR antigen mismatches were similar between all groups. KTRs with exclusions had significantly lower class II eplet mismatches (20.4) than the contemporary DD KTRs without exclusions (63.7) and DD KTRs transplanted in the preceding decade (46.9). dnDSAs were identified in two of eight DD KTRs with exclusions, two of three DD KTRs without exclusions and five of eight LD KTRs. Epitope-based allocation achieved timely access to transplantation, low class II eplet mismatches, and low rates of dnDSAs in the first year. This strategy requires longer follow-up and larger numbers, but has the potential to reduce anti-HLA sensitization and improve both graft survival and opportunities for future retransplantation.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16351
DOI: 10.1111/petr.12815
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/27662811
Type: Journal Article
Subjects: Donor-specific antibody
Epitope
Kidney
Pediatric
Transplant
Appears in Collections:Journal articles

Show full item record

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.