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dc.contributor.authorPalesi, Fulviaen_US
dc.contributor.authorTournier, Jacques-Donalden_US
dc.contributor.authorCalamante, Fernandoen_US
dc.contributor.authorMuhlert, Nilsen_US
dc.contributor.authorCastellazzi, Gloriaen_US
dc.contributor.authorChard, Declanen_US
dc.contributor.authorD'Angelo, Egidioen_US
dc.contributor.authorWheeler-Kingshott, Claudia AMen_US
dc.identifier.citationBrain Structure and Function 2015;220(6):3369-3384en_US
dc.description.abstractIn addition to motor functions, it has become clear that in humans the cerebellum plays a significant role in cognition too, through connections with associative areas in the cerebral cortex. Classical anatomy indicates that neo-cerebellar regions are connected with the contralateral cerebral cortex through the dentate nucleus, superior cerebellar peduncle, red nucleus and ventrolateral anterior nucleus of the thalamus. The anatomical existence of these connections has been demonstrated using virus retrograde transport techniques in monkeys and rats ex vivo. In this study, using advanced diffusion MRI tractography we show that it is possible to calculate streamlines to reconstruct the pathway connecting the cerebellar cortex with contralateral cerebral cortex in humans in vivo. Corresponding areas of the cerebellar and cerebral cortex encompassed similar proportion (about 80%) of the tract, suggesting that the majority of streamlines passing through the superior cerebellar peduncle connect the cerebellar hemispheres through the ventrolateral thalamus with contralateral associative areas. This result demonstrates that this kind of tractography is a useful tool to map connections between the cerebellum and the cerebral cortex and moreover could be used to support specific theories about the abnormal communication along these pathways in cognitive dysfunctions in pathologies ranging from dyslexia to autism.en_US
dc.subjectCerebral cortexen_US
dc.subjectDiffusion MRIen_US
dc.subjectMRI tractographyen_US
dc.titleContralateral cerebello-thalamo-cortical pathways with prominent involvement of associative areas in humans in vivoen_US
dc.typeJournal Articleen_US
dc.identifier.affiliationDepartment of Physics, University of Pavia, Pavia, Italyen_US
dc.identifier.affiliationBrain Connectivity Center, C. Mondino National Neurological Institute, Pavia, Italyen_US
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Medicine, Austin Health and Northern Health, University of Melbourne, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Neuroinflammation, NMR Research Unit, Queen Square MS Centre, UCL Institute of Neurology, London, UKen_US
dc.identifier.affiliationDepartment of Psychology, Cardiff University, Cardiff, UKen_US
dc.identifier.affiliationDepartment of Industrial and Information Engineering, University of Pavia, Pavia, Italyen_US
dc.identifier.affiliationNational Institute for Health Research, University College London Hospitals Biomedical Research Centre, London, UKen_US
dc.identifier.affiliationDepartment of Brain and Behavioural Sciences, University of Pavia, Pavia, Italyen_US
dc.type.austinJournal Articleen_US
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
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