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Title: Contralateral cerebello-thalamo-cortical pathways with prominent involvement of associative areas in humans in vivo
Austin Authors: Palesi, Fulvia;Tournier, Jacques-Donald;Calamante, Fernando;Muhlert, Nils;Castellazzi, Gloria;Chard, Declan;D'Angelo, Egidio;Wheeler-Kingshott, Claudia AM
Affiliation: Department of Physics, University of Pavia, Pavia, Italy
Brain Connectivity Center, C. Mondino National Neurological Institute, Pavia, Italy
The Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, Heidelberg, Victoria, Australia
Department of Medicine, Austin Health and Northern Health, University of Melbourne, Heidelberg, Victoria, Australia
Department of Neuroinflammation, NMR Research Unit, Queen Square MS Centre, UCL Institute of Neurology, London, UK
Department of Psychology, Cardiff University, Cardiff, UK
Department of Industrial and Information Engineering, University of Pavia, Pavia, Italy
National Institute for Health Research, University College London Hospitals Biomedical Research Centre, London, UK
Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy
Issue Date: Nov-2015 2014-08-19
Publication information: Brain Structure and Function 2015;220(6):3369-3384
Abstract: In addition to motor functions, it has become clear that in humans the cerebellum plays a significant role in cognition too, through connections with associative areas in the cerebral cortex. Classical anatomy indicates that neo-cerebellar regions are connected with the contralateral cerebral cortex through the dentate nucleus, superior cerebellar peduncle, red nucleus and ventrolateral anterior nucleus of the thalamus. The anatomical existence of these connections has been demonstrated using virus retrograde transport techniques in monkeys and rats ex vivo. In this study, using advanced diffusion MRI tractography we show that it is possible to calculate streamlines to reconstruct the pathway connecting the cerebellar cortex with contralateral cerebral cortex in humans in vivo. Corresponding areas of the cerebellar and cerebral cortex encompassed similar proportion (about 80%) of the tract, suggesting that the majority of streamlines passing through the superior cerebellar peduncle connect the cerebellar hemispheres through the ventrolateral thalamus with contralateral associative areas. This result demonstrates that this kind of tractography is a useful tool to map connections between the cerebellum and the cerebral cortex and moreover could be used to support specific theories about the abnormal communication along these pathways in cognitive dysfunctions in pathologies ranging from dyslexia to autism.
DOI: 10.1007/s00429-014-0861-2
PubMed URL:
Type: Journal Article
Subjects: Cerebellum
Cerebral cortex
Diffusion MRI
MRI tractography
Appears in Collections:Journal articles

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