Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16037
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dc.contributor.authorGraudins, Linda Velta-
dc.contributor.authorTrubiano, Jason-
dc.contributor.authorAung, Ar Kar-
dc.contributor.authorLy, Jenny-
dc.date2016-06-06-
dc.date.accessioned2016-06-10T01:12:03Z-
dc.date.available2016-06-10T01:12:03Z-
dc.date.issued2016-06-06-
dc.identifier.citationBritish journal of clinical pharmacology 2016; 82(4): 1040-1047en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16037-
dc.description.abstractAIMS: To determine the gaps in practice regarding appropriate ADR documentation and risk communication for patients diagnosed with severe cutaneous adverse drug reactions (CADR). METHODS: This was a retrospective observational cohort study conducted using hospital coding and databases to identify inpatients diagnosed with CADR from January 2004 to August 2014. Hospital discharge summaries, ADR reports and pharmacy dispensing records were reviewed for ADR documentation. Patients, who were still living in Australia and did not opt out of being contacted, were invited to be surveyed by telephone to determine their understanding of recommendations, re-exposure rates and long-term effects. RESULTS: Of 85 patients identified, median age was 59 (IQR 44 - 72) years and 47.1% were male. The most common diagnosis was TENS (49.4 %). Ten patients (11.8%) died as inpatients. Of the 81 patients with a drug-related causality, 47 (58%) had appropriate documentation in all three required medical record platforms. Of the 56 eligible patients, 38 (67.9 %) were surveyed; 13% had no information provided upon discharge and26.3% patients had a mismatch in knowledge of implicated medications. No surveyed patient had a relapse of CADR, but 23.7% had a subsequent unrelated allergic reaction. Thirteen patients (34.2%) reported long term effects. CONCLUSIONS: We found gaps in the accuracy of ADR documentation and communication of risk at discharge, which indicated risks to patient safety. Electronic systems are being developed to improve documentation. Written information about CADR is being provided at discharge to improve patient understanding and knowledge.en_US
dc.subjectCADRen_US
dc.subjectSteven-Johnson syndromeen_US
dc.subjectMedication safetyen_US
dc.subjectDrug allergyen_US
dc.subjectadverse drug reaction-
dc.subjectcutaneous reactions-
dc.titleMore than skin deep. Ten year follow up of delayed cutaneous adverse drug reactions (CADR)en_US
dc.typeJournal Article-
dc.identifier.journaltitleBritish Journal of Clinical Pharmacologyen_US
dc.identifier.affiliationPharmacy Department, Alfred Health, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Infectious Diseases, Alfred Health, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Infectious Diseases, Peter MacCallum Cancer Centre, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of General Medicine, Alfred Health and Monash University, Victoria, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/27265387en_US
dc.identifier.doi10.1111/bcp.13030en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
dc.type.austinObservational Study-
local.name.researcherTrubiano, Jason-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCentre for Antibiotic Allergy and Research-
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