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Title: Brain lesions and delayed water maze learning deficits after intracerebroventricular spermine.
Austin Authors: Conway, Elizabeth L
Affiliation: University of Melbourne, Clinical Pharmacology and Therapeutics Unit, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria 3084, Australia
Issue Date: 27-Jul-1998
Publication information: Brain Research; 800(1): 10-20
Abstract: The effects of spermine on the acquisition and retention of spatial learning in the Morris water maze were studied. Spermine 25 and 125 nmol i.c.v. did not alter the ability of rats to find a hidden platform in the water maze when administered before training over 5 days. However, the inhibitory effect of the benzodiazepine, diazepam (3 mg/kg i.p., 30 min prior to training), on path length to target was markedly potentiated by the higher dose of spermine, consistent with spermine acting as a functional antagonist at the NMDA receptor. This drug combination did not affect performance on visible platform trials. Administration of doses of 125 and 250 nmol (but not 62.5 nmol) of spermine i.c.v. in the week prior to training (daily for 5 days) dose-dependently inhibited subsequent learning of a platform position in the absence of drug. These higher doses of spermine produced neuronal loss and increased [3H]PK11195 binding indicating microglial activation predominantly in the hippocampus and to a lesser extent in the striatum, septum, thalamus and amygdala. Spermine 125 nmol i.c.v. (daily for 7 days) also abolished retention of a previously learned platform position when administered in an interval between training and retention testing. The inhibitory effects of spermine 125 nmol i.c.v. (daily for 7 days) on subsequent spatial learning were not antagonised by concomitant administration of 30 nmol dizocilpine. These results demonstrate that spermine produces a delayed neurotoxic effect in particular neuronal populations in the brain that selectively impair spatial learning and recall.
Gov't Doc #: 9685571
Journal: Brain Research
Type: Journal Article
Subjects: Animals
Brain.drug effects.metabolism.pathology
Cerebral Ventricles.drug effects.pathology.physiology
Injections, Intraventricular
Learning Disorders.chemically induced.physiopathology
Maze Learning.drug effects
Memory.drug effects
Rats, Wistar
Receptors, N-Methyl-D-Aspartate.antagonists & inhibitors
Spermine.administration & dosage.toxicity
Time Factors
Appears in Collections:Journal articles

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