Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13612
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dc.contributor.authorBurazin, T Cen
dc.contributor.authorGundlach, Andrew Len
dc.date.accessioned2015-05-16T03:29:58Z
dc.date.available2015-05-16T03:29:58Z
dc.date.issued1998-08-01en
dc.identifier.citationJournal of Neurochemistry; 71(2): 879-82en
dc.identifier.govdoc9681481en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/13612en
dc.description.abstractGalanin has been ascribed several physiological roles that are thought to be mediated via multiple galanin receptors. Recently, two galanin receptors--galanin receptor-1 (GalR1) and galanin receptor-2 (GalR2)--have been cloned and characterized and shown to have differences in amino acid sequence, pharmacology, and second messenger signaling systems. Previous studies have demonstrated an up-regulation of galanin expression in damaged neurons of several different types. Using in situ hybridization histochemistry this study investigated whether adult cranial motor neurons express mRNAs encoding GalR1 and/or GalR2 and explored possible time-dependent changes in these transcripts following facial nerve injury. GalR2 mRNA levels were increased in the ipsilateral facial nucleus 3 (approximately 1.8-fold) and 7 days (approximately 3.7-fold) after unilateral facial nerve crush and had returned to levels equivalent to those in contralateral controls by 14-21 days. GalR1 mRNA was not detected in facial nuclei of naive, sham-operated, or operated rats but was present in adjacent reticular nuclei. Galanin mRNA levels were also increased eight- to 10-fold in the ipsilateral facial nucleus following nerve injury. These experiments confirm the putative importance of galanin signaling systems after nerve injury by demonstrating a differential response of galanin receptor subtypes and suggest an important "autoreceptor" role for the GalR2 receptor in these processes.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherAutoreceptors.genetics.metabolismen
dc.subject.otherFacial Nerve.cytology.metabolismen
dc.subject.otherFacial Nerve Injuriesen
dc.subject.otherGalanin.metabolismen
dc.subject.otherGene Expression.physiologyen
dc.subject.otherIn Situ Hybridizationen
dc.subject.otherMaleen
dc.subject.otherMotor Neurons.chemistry.metabolismen
dc.subject.otherNerve Regeneration.physiologyen
dc.subject.otherNeuronal Plasticity.physiologyen
dc.subject.otherRNA, Messenger.metabolismen
dc.subject.otherRatsen
dc.subject.otherRats, Sprague-Dawleyen
dc.subject.otherReceptors, Galaninen
dc.subject.otherReceptors, Neuropeptide.genetics.metabolismen
dc.titleInducible galanin and GalR2 receptor system in motor neuron injury and regeneration.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of neurochemistryen
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin & Repatriation Medical Centre, Heidelberg, Victoria, Australiaen
dc.description.pages879-82en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/9681481en
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.cerifentitytypePublications-
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