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Title: Localization of mRNA for the apoptosis-linked gene ALG-2 in young and aged rat brain.
Austin Authors: Venn, M K;Conway, Elizabeth L
Affiliation: University of Melbourne, Department of Medicine, Austin Campus, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
Issue Date: 22-Jun-1998
Publication information: Neuroreport; 9(9): 1981-5
Abstract: ALG-2 is a recently described pro-apoptosis gene that codes for a Ca2+-binding protein involved in T-cell receptor-, Fas- and glucocorticoid-induced cell death. We have used in situ hybridization histochemistry to examine the regional distribution of ALG-2 mRNA in the brain of 3- and 24-month old rats. There was widespread, predominantly neuronal distribution of ALG-2 mRNA throughout the brain. Areas expressing high levels included the granule and pyramidal cell layers of the hippocampus, choroid plexus, area postrema, and a number of hindbrain nuclei. ALG-2 mRNA levels in aged rats were not significantly different to young animals. The pattern of expression of ALG-2 mRNA in adult brain is similar to other apoptosis-related genes and suggests it may be involved in neuronal survival.
Gov't Doc #: 9674578
Type: Journal Article
Subjects: Aging.genetics.metabolism
Brain Chemistry.genetics
In Situ Hybridization
Nerve Degeneration.pathology
RNA Probes
RNA, Messenger.biosynthesis
Rats, Wistar
Appears in Collections:Journal articles

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