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|Title:||Localization of mRNA for the apoptosis-linked gene ALG-2 in young and aged rat brain.||Austin Authors:||Venn, M K;Conway, Elizabeth L||Affiliation:||University of Melbourne, Department of Medicine, Austin Campus, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia||Issue Date:||22-Jun-1998||Publication information:||Neuroreport; 9(9): 1981-5||Abstract:||ALG-2 is a recently described pro-apoptosis gene that codes for a Ca2+-binding protein involved in T-cell receptor-, Fas- and glucocorticoid-induced cell death. We have used in situ hybridization histochemistry to examine the regional distribution of ALG-2 mRNA in the brain of 3- and 24-month old rats. There was widespread, predominantly neuronal distribution of ALG-2 mRNA throughout the brain. Areas expressing high levels included the granule and pyramidal cell layers of the hippocampus, choroid plexus, area postrema, and a number of hindbrain nuclei. ALG-2 mRNA levels in aged rats were not significantly different to young animals. The pattern of expression of ALG-2 mRNA in adult brain is similar to other apoptosis-related genes and suggests it may be involved in neuronal survival.||Gov't Doc #:||9674578||URI:||http://ahro.austin.org.au/austinjspui/handle/1/13609||URL:||https://pubmed.ncbi.nlm.nih.gov/9674578||Type:||Journal Article||Subjects:||Aging.genetics.metabolism
In Situ Hybridization
|Appears in Collections:||Journal articles|
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