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Title: Aminoguanidine has an anti-atherogenic effect in the cholesterol-fed rabbit.
Austin Authors: Panagiotopoulos, Sianna ;O'Brien, R C;Bucala, R;Cooper, Mark E;Jerums, George 
Affiliation: Department of Medicine, Austin and Repatriation Medical Centre (Austin Campus), University of Melbourne, Heidelberg, Australia
Issue Date: 1-Jan-1998
Publication information: Atherosclerosis; 136(1): 125-31
Abstract: Advanced glycosylation endproducts (AGEs) which result from the non-enzymatic interaction of proteins and glucose are implicated in the vasculopathy of diabetes and aging. Since aminoguanidine (A) inhibits the accumulation of AGEs, we explored its effects on the development of atherosclerosis. Male New Zealand white cross rabbits fed a high cholesterol (1%) diet were randomized to control (C) or increasing doses of A treatment (25, 50 and 100 mg/kg A body weight). The animals were sacrificed after 12 weeks. Sudan IV was used to stain the lipid containing plaques of the aortic arch, thoracic and abdominal aorta and the surface area occupied by atheroma was assessed. Increasing doses of A treatment were associated with reduction in plaque formation in the aorta. At a dose of 100 mg/kg A, there was a 30, 49 and 48% reduction in plaque formation in the aortic arch, thoracic and abdominal aorta, respectively. There was a correlation between AGE levels and the degree of atheroma in these cholesterol fed rabbits (control, r = 0.75, P < 0.01; 100 mg/kg A, r = 0.59, P = 0.02). These data suggest that advanced glycation may participate in atherogenesis and raise the possibility that inhibitors of advanced glycation may retard this process.
Gov't Doc #: 9544739
ORCID: 0000-0002-0845-0001
Type: Journal Article
Subjects: Animals
Arteriosclerosis.prevention & control
Cholesterol, Dietary.pharmacology
Enzyme Inhibitors.therapeutic use
Glycosylation End Products, Advanced.metabolism
Guanidines.blood.therapeutic use
Pilot Projects
Thiobarbituric Acid Reactive Substances.metabolism
Appears in Collections:Journal articles

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