Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13585
Full metadata record
DC FieldValueLanguage
dc.contributor.authorRyan, M Cen
dc.contributor.authorGundlach, Andrew Len
dc.date.accessioned2015-05-16T03:28:05Z
dc.date.available2015-05-16T03:28:05Z
dc.date.issued1998-02-10en
dc.identifier.citationBrain Research. Developmental Brain Research; 105(2): 251-68en
dc.identifier.govdoc9541743en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/13585en
dc.description.abstractThe central natriuretic peptide system is composed of at least three structurally homologous and uniquely distributed peptides and receptors which are thought to be involved in the central regulation of cardiovascular and autonomic function and more recently been shown to affect cellular growth and proliferation, processes pertinent to mammalian development. As such, following our initial mapping of preproatrial natriuretic peptide (ppANP) mRNA in adult brain [M.C. Ryan, A.L. Gundlach, Anatomical localization of preproatrial natriuretic peptide mRNA in the rat brain by in situ hybridization histochemistry: in olfactory regions, J. Comp. Neurol., 356 (1995) 168-182], it was of interest to determine the ontogenic expression of natriuretic peptide mRNAs in the developing rat brain. Using in situ hybridization histochemistry of specific [35S]- or [33P]-labeled oligonucleotides, ppANP and preproC-type natriuretic peptide (ppCNP) mRNAs were detected in the developing rat brain from postnatal day 4 to day 60 (adult). PpANP mRNA was observed in many hindbrain, but only some forebrain, regions at postnatal day 4. Regional differences in the temporal expression of ppANP mRNA were apparent with ppANP mRNA detected in the medial preoptic area, mammillary nuclei and medial habenular nucleus at postnatal day 4 and in other areas including the arcuate and dorsomedial hypothalamic nuclei and in olfactory and limbic regions at postnatal day 10. A number of regions also exhibited transient expression of ppANP mRNA such as the bed nucleus of the stria terminalis and the medial cerebellar nucleus. In contrast, ppCNP mRNA was detected at relatively high levels in several regions on postnatal day 4 including olfactory nuclei, the hippocampus and particularly the pontine nucleus. The level of expression appeared to increase markedly in most regions including forebrain olfactory and hippocampal areas and in brainstem regions including the pontine nucleus, the parvocellular and lateral reticular and spinal trigeminal nuclei by postnatal days 10 and 13, but decreased from this peak to equivalent to adult levels by postnatal day 28. The differential and transient expression of the natriuretic peptides during postnatal development, together with previous reports of the ontogenic regulation of natriuretic peptide receptor expression and binding patterns, further suggests their involvement in developmental processes in the rat CNS and provides information relevant to the likely functional development of natriuretic peptide-utilizing pathways.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherAnimals, Newbornen
dc.subject.otherAtrial Natriuretic Factor.biosynthesis.geneticsen
dc.subject.otherBrain.growth & developmenten
dc.subject.otherBrain Chemistry.drug effects.physiologyen
dc.subject.otherFemaleen
dc.subject.otherImmunohistochemistryen
dc.subject.otherIn Situ Hybridizationen
dc.subject.otherMaleen
dc.subject.otherOligonucleotide Probesen
dc.subject.otherProtein Precursors.biosynthesis.geneticsen
dc.subject.otherRNA, Messenger.biosynthesis.geneticsen
dc.subject.otherRatsen
dc.subject.otherRats, Sprague-Dawleyen
dc.titleOntogenic expression of natriuretic peptide mRNAs in postnatal rat brain: implications for development?en
dc.typeJournal Articleen
dc.identifier.journaltitleBrain Research. Developmental Brain Researchen
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Australiaen
dc.description.pages251-68en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/9541743en
dc.type.austinJournal Articleen
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

2
checked on Feb 6, 2023

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.