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dc.contributor.authorVerberne, Anthony J Men
dc.contributor.authorLam, Wen
dc.contributor.authorOwens, N Cen
dc.contributor.authorSartor, Daniela Men
dc.identifier.citationClinical and Experimental Pharmacology & Physiology; 24(9-10): 748-54en
dc.description.abstract1. Supramedullary structures including the ventral medial prefrontal cortex (MPFC) and the midbrain cuneiform nucleus (CnF) project directly and indirectly to premotor sympatho-excitatory neurons of the rostral ventrolateral medulla (RVLM) that are critically involved in the generation of sympathetic vasomotor tone. 2. Electrophysiological studies have demonstrated that activation of depressor sites within the MPFC is associated with splanchnic sympathetic vasomotor inhibition and inhibition of the activity of RVLM sympathoexcitatory neurons. 3. Antidromic mapping and anatomical studies support the notion that a relay in the nucleus tractus solitarius is involved in the cardiovascular response to MPFC stimulation. 4. The midbrain CnF, which lies adjacent to the midbrain periaqueductal grey, is a sympathoexcitatory region of the midbrain reticular formation. Sympathoexcitatory responses evoked from the CnF are associated with short-latency excitation of RVLM neurons. 5. Cuneiform nucleus stimulation induces the expression of mRNA for the immediate early genes c-fos and NGFI-A in mid-brain, pontine and hypothalamic structures. 6. The MPFC and CnF are supramedullary structures with opposing modulatory influences on sympathetic vasomotor drive, whose roles in cardiovascular control mechanisms warrant further investigation.en
dc.subject.otherAutonomic Pathways.physiologyen
dc.subject.otherMedulla Oblongata.physiologyen
dc.subject.otherMuscle, Smooth, Vascular.innervation.physiologyen
dc.subject.otherNeurotransmitter Agents.physiologyen
dc.subject.otherSympathetic Nervous System.physiologyen
dc.titleSupramedullary modulation of sympathetic vasomotor function.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical and Experimental Pharmacology & Physiologyen
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Victoria, Australiaen
dc.type.austinJournal Articleen
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristype Pharmacology and Therapeutics- (University of Melbourne)-
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