Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13537
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dc.contributor.authorJenkins, T Aen
dc.contributor.authorChai, Syn Yen
dc.contributor.authorMendelsohn, Frederick AOen
dc.date.accessioned2015-05-16T03:24:43Z
dc.date.available2015-05-16T03:24:43Z
dc.date.issued1997-07-08en
dc.identifier.citationClinical and Experimental Hypertension (new York, N.y. : 1993); 19(5-6): 645-58en
dc.identifier.govdoc9247745en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/13537en
dc.description.abstractWe have previously demonstrated that angiotensin II stimulates the release of dopamine from the normotensive rat striatum via the AT1 receptor. In this study, the effect of angiotensin II-stimulated striatal dopamine release in the spontaneous hypertensive rat was compared to normotensive controls. In the spontaneous hypertensive rat, angiotensin II stimulated dopamine release to 169 +/- 13% (P < 0.05) in the experimental period, with levels remaining high in the recovery phase, 158 +/- 16% (P < 0.05). This effect was not significantly different from the response in normotensive controls, in which angiotensin II stimulated dopamine release to 149 +/- 18% (P < 0.05) in the experimental period, with the effect also persisting through the recovery period, 244 +/- 62% (P < 0.05). Thus, despite reports of increased activity of the brain angiotensin II and dopamine systems in the spontaneous hypertensive rat, there is no evidence of abnormal regulation of the striatonigral dopamine system.en
dc.language.isoenen
dc.subject.otherAngiotensin II.pharmacologyen
dc.subject.otherAnimalsen
dc.subject.otherCorpus Striatum.drug effects.secretionen
dc.subject.otherDopamine.secretionen
dc.subject.otherHypertension.physiopathologyen
dc.subject.otherMicrodialysisen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred SHRen
dc.subject.otherRats, Sprague-Dawleyen
dc.subject.otherSpecies Specificityen
dc.titleEffect of angiotensin II on striatal dopamine release in the spontaneous hypertensive rat.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical and experimental hypertension (New York, N.Y. : 1993)en
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australiaen
dc.description.pages645-58en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/9247745en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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