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Title: Computerized neuropsychological tests in the early detection of dementia: prospective findings.
Austin Authors: Fowler, K S;Saling, Michael M ;Conway, Elizabeth L;Semple, J M;Louis, William J 
Affiliation: Department of Clinical Pharmacology and Therapeutics, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Mar-1997
Publication information: Journal of the International Neuropsychological Society : Jins; 3(2): 139-46
Abstract: This longitudinal study examines the sensitivity of 2 computerized neuropsychological tests, delayed matching to sample and paired associate learning, to early dementia of the Alzheimer type (DAT). Normal controls, patients in the early stages of DAT, and individuals with questionable dementia (QD) were studied. At 6 and 12 months after initial presentation, almost half of the QD group exhibited lower scores on the computerized subtests, maintaining their scores on standard testing. Over the same period NC subjects maintained their performance levels, while DAT patients continued to deteriorate. Linear discriminant function analyses of the computerized subtests at 6 and 12 months correctly classified 100% of the early DAT patients. Eighty-four and 79 percent of normal controls were correctly classified at 6 and 12 months respectively. Further development of these subtests for the detection of early dementia and the documentation of ongoing change in DAT is warranted. The findings are discussed in terms of the special sensitivity of these tests to the neuropathology of Alzheimer's Disease.
Gov't Doc #: 9126855
Journal: Journal of the International Neuropsychological Society : JINS
Type: Journal Article
Subjects: Aged
Alzheimer Disease.classification.diagnosis.psychology
Diagnosis, Computer-Assisted.statistics & numerical data
Discrimination Learning
Longitudinal Studies
Mental Recall
Middle Aged
Neuropsychological Tests.statistics & numerical data
Paired-Associate Learning
Pattern Recognition, Visual
Prospective Studies
Sensitivity and Specificity
Appears in Collections:Journal articles

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