Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13513
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dc.contributor.authorCraven, J Aen
dc.contributor.authorConway, Elizabeth Len
dc.date.accessioned2015-05-16T03:23:02Z
dc.date.available2015-05-16T03:23:02Z
dc.date.issued1997-02-01en
dc.identifier.citationClinical and Experimental Pharmacology & Physiology; 24(2): 204-7en
dc.identifier.govdoc9075597en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/13513en
dc.description.abstract1. In the present study the neuroprotective effects of 3 mg/kg idazoxan, an alpha 2-adrenoceptor antagonist and imidazoline2-receptor (I2-receptor) ligand, 3 mg/kg methoxyidazoxan, a specific alpha 2-adrenoceptor antagonist, and 0.6 and 3 mg/kg BU224, a selective I2-receptor ligand, were evaluated following 10 min of global ischaemia in rats. 2. Neuronal cell counts in the CA1 region of the hippocampus 8 days postischaemia indicated 46-96% cell loss compared with control (P < 0.001) and a 320% increase in [3H]-PK11195 binding (P < 0.001) used as a marker of gliosis. No significant neuroprotective effect could be detected on these markers of neuronal damage in the active treatment groups. In a subset of idazoxan-treated rats, neuronal loss and gliosis was minimal. 3. Mean body temperature over 3 h postischaemia was lower in idazoxan-treated rats than in the other treatment groups (P < 0.001) and there was a correlation between mean body temperature and cell counts (P < 0.01) and mean body temperature and gliosis in this group (P = 0.057). 4. These results indicate that at the doses used neither BU224 nor methoxyidazoxan are neuroprotective in this ischaemia model and they raise the possibility that any neuroprotective effect of idazoxan may be related to hypothermic effects of the drug.en
dc.language.isoenen
dc.subject.otherAdrenergic alpha-2 Receptor Antagonistsen
dc.subject.otherAdrenergic alpha-Antagonists.pharmacologyen
dc.subject.otherAnimalsen
dc.subject.otherBrain Ischemia.metabolism.pathologyen
dc.subject.otherHippocampus.pathologyen
dc.subject.otherIdazoxan.analogs & derivatives.pharmacologyen
dc.subject.otherImidazoles.metabolism.pharmacologyen
dc.subject.otherImidazoline Receptorsen
dc.subject.otherLigandsen
dc.subject.otherMaleen
dc.subject.otherNeurons.drug effects.pathologyen
dc.subject.otherRatsen
dc.subject.otherRats, Wistaren
dc.subject.otherReceptors, Drug.metabolismen
dc.titleEffects of alpha 2-adrenoceptor antagonists and imidazoline2-receptor ligands on neuronal damage in global ischaemia in the rat.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical and Experimental Pharmacology & Physiologyen
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin & Repatriation Medical Centre, Heidelberg, Victoria, Australiaen
dc.description.pages204-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/9075597en
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.cerifentitytypePublications-
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