Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13511
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dc.contributor.authorMaguire, Ken
dc.contributor.authorCheung, Pen
dc.contributor.authorCrowley, Ken
dc.contributor.authorNorman, Trevor Ren
dc.contributor.authorSchweitzer, Ien
dc.contributor.authorBurrows, Graham Den
dc.date.accessioned2015-05-16T03:22:54Z
dc.date.available2015-05-16T03:22:54Z
dc.date.issued1997-01-17en
dc.identifier.citationSchizophrenia Research; 23(1): 61-7en
dc.identifier.govdoc9050129en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13511en
dc.description.abstractForty schizophrenic patients were included in a study of the relationship between serotonin function as measured by 3H-paroxetine binding to platelet membranes and aggressive behaviour. Patients classified as either aggressive or non-aggressive were paired by age, sex and duration of illness. 3H-Paroxetine binding variations were avoided by taking samples for each pair between 09:00 and 11:00 h, within 4 days of each other, and by assaying pair of samples together. The mean Kd for the aggressive group was 0.193 +/- 0.126 nM and the mean Kd for the non-aggressive group was 0.176 +/- 0.164 nM. The mean Bmax for the aggressive group was 1451 +/- 386 fmol/mg protein while the mean for the non-aggressive group was 1549 +/- 375 fmol/mg protein. There was no significant difference between the groups for either parameter, Kd or Bmax. There were no significant correlations between psychopathology rating including positive and negative symptoms, depression, suicidal thoughts, impulse control, as well as both past and present history of aggression, hostility and irritability traits, psychopathic deviance and either Bmax and Kd. This study finds no relationship between aggressive behaviour and peripheral serotonin function as measured by 3H-paroxetine binding to platelet membranes.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAggression.physiology.psychologyen
dc.subject.otherBlood Platelets.metabolismen
dc.subject.otherCarrier Proteins.metabolismen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherParoxetine.pharmacokineticsen
dc.subject.otherPsychiatric Status Rating Scalesen
dc.subject.otherReceptors, Drug.metabolismen
dc.subject.otherReceptors, Serotonin.physiologyen
dc.subject.otherSchizophrenia.physiopathologyen
dc.subject.otherSchizophrenic Psychologyen
dc.subject.otherSerotonin.physiologyen
dc.subject.otherSerotonin Uptake Inhibitors.pharmacokineticsen
dc.titleAggressive behaviour and platelet 3H-paroxetine binding in schizophrenia.en
dc.typeJournal Articleen
dc.identifier.journaltitleSchizophrenia researchen
dc.identifier.affiliationDepartment of Psychiatry, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1016/S0920-9964(96)00092-8en
dc.description.pages61-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/9050129en
dc.type.austinJournal Articleen
local.name.researcherNorman, Trevor R
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptPsychiatry (University of Melbourne)-
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