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Title: Polyarteritis nodosa and antiglomerular basement membrane disease without antineutrophil cytoplasm antibodies.
Austin Authors: Kirkland, G S;Savige, Judy A;Sinclair, R A;Hennessy, O F
Affiliation: Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 16-May-1996
Publication information: American Journal of Nephrology; 16(5): 442-5
Abstract: Antiglomerular basement membrane (GBM) antibodies have been described previously in patients with microscopic polyarteritis but not in patients with polyarteritis nodosa alone. Where anti-GBM antibodies occur in microscopic polyarteritis, antineutrophil cytoplasm antibodies (ANCA) are usually present. We describe here a patient with polyarteritis nodosa and anti-GBM antibodies in whom ANCA could not be demonstrated. A 72-year-old woman presented with abdominal pain, diarrhoea and acute renal failure. A renal biopsy showed crescentic glomerulonephritis and linear immunofluorescence of the GBM consistent with anti-GBM disease. In addition, there was evidence of large-and medium-sized vessel vasculitis on abdominal angiography, performed because of persisting abdominal pain. There was no small vessel vasculitis on histological examination of the renal biopsy and ANCA could not be demonstrated by indirect immunofluorescence or ELISA.
Gov't Doc #: 8886183
Journal: American journal of nephrology
Type: Journal Article
Subjects: Acute Kidney Injury.etiology.immunology.pathology
Antibodies, Antineutrophil Cytoplasmic.immunology
Basement Membrane.immunology.pathology
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique, Indirect
Kidney Glomerulus.immunology.pathology
Polyarteritis Nodosa.complications.immunology.pathology
Appears in Collections:Journal articles

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