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Title: Premedication with cyclosporine and perindopril modifies the ischaemia-reperfusion injury during liver resection in rats.
Austin Authors: Hardy, Kenneth John;Tancheroen, S;Shulkes, Arthur
Affiliation: University of Melbourne, Department of Surgery, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Jul-1996
Publication information: Journal of Gastroenterology and Hepatology; 11(7): 652-7
Abstract: The aim of the present study was to determine whether pretreatment with cyclosporine (CsA), or perindopril (an angiotensin converting enzyme inhibitor) would modify the ischaemia-reperfusion injury of vascular occlusion during liver resection. Rats were allocated to four groups (n = 20 for each group): (i) sham operated; (ii) liver resection only; (iii) CsA (15 mg/kg); and (iv) perindopril (4 mg/kg during the three days before ischaemia-reperfusion injury with liver resection). The ischaemia was produced by a 30 min continuous occlusion. The model was designed to study liver function tests as the principal parameter. Compared with liver resection only, bilirubin was significantly lower with perindopril on days 8 and 23, but significantly higher with CsA on days 1 and 2. The alanine aminotransferase peak (day 1) was significantly lower with both perindopril and CsA. The prothrombin time was significantly less on days 2 and 4 with perindopril and day 4 with CsA. Liver histological changes were minimal in all groups at 30 min ischaemia, but were significantly less severe in the perindopril group. There was a significant decrease in the weight of the regenerated liver at day 23 with perindopril and a significantly lower drop in weight on day 1 and the rate of gain was significantly greater. Perindopril (4 mg/kg) and CsA (15 mg/kg) significantly alter liver function tests, liver histology and bodyweight following an ischaemia-reperfusion injury associated with liver resection. These findings could limit ischaemia-reperfusion injury for major liver resections in the clinical setting.
Gov't Doc #: 8840241
Journal: Journal of Gastroenterology and Hepatology
Type: Journal Article
Subjects: Angiotensin-Converting Enzyme Inhibitors.therapeutic use
Body Weight
Cyclosporine.therapeutic use
Immunosuppressive Agents.therapeutic use
Indoles.therapeutic use
Liver Function Tests
Organ Size
Prothrombin Time
Rats, Wistar
Reperfusion Injury.drug therapy.physiopathology
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