Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13473
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dc.contributor.authorDawson, M Jen
dc.contributor.authorTrapani, Joseph Aen
dc.date.accessioned2015-05-16T03:19:45Z
dc.date.available2015-05-16T03:19:45Z
dc.date.issued1996-09-01en
dc.identifier.citationJournal of Leukocyte Biology; 60(3): 310-6en
dc.identifier.govdoc8830786en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/13473en
dc.description.abstractIn recent years a novel family of interferon (IFN)-inducible nuclear proteins has been identified in both mouse and humans and implicated in the control of myeloid differentiation. Recent evidence suggests that this role may be mediated by an effect on cell cycle regulation through interaction with known transcriptional regulators. Our laboratory first identified a nuclear protein designated IFI 16, which is strongly inducible with IFN-alpha and -gamma in myeloid cells. IFI 16 shares homology with at least six IFN-inducible mouse genes, designated the Gene 200 cluster, and also has close similarity with the human myeloid cell nuclear differentiation antigen, whose expression has also been associated with later stages of normal myelopoiesis and some myeloid malignancies. The structural hallmark of each protein in this family of hemopoietic IFN-inducible nuclear proteins is a 200-amino acid motif (hence HIN-200), present singly or as a tandem repeat. The restricted expression of these proteins, their ability to bind to nucleic acid, and their expression in response to a variety of stimuli eliciting myeloid differentiation strongly suggest that they play a role in hemopoietic maturation.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBase Sequenceen
dc.subject.otherHumansen
dc.subject.otherInterferons.physiologyen
dc.subject.otherLeukocytes.metabolismen
dc.subject.otherMiceen
dc.subject.otherMolecular Sequence Dataen
dc.subject.otherNuclear Proteins.biosynthesisen
dc.subject.otherSequence Homology, Nucleic Aciden
dc.titleHIN-200: a novel family of IFN-inducible nuclear proteins expressed in leukocytes.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of leukocyte biologyen
dc.identifier.affiliationCellular Cytotoxicity Laboratory, Austin Research Institute, Austin Hospital, Heidelberg, Australiaen
dc.description.pages310-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/8830786en
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.cerifentitytypePublications-
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