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Title: Interactions of angiotensin II with central dopamine.
Austin Authors: Jenkins, T A;Allen, A M;Chai, Syn Y;MacGregor, Duncan;Paxinos, G;Mendelsohn, Frederick AO
Affiliation: University of Melbourne, Department of Medicine, Austin Hospital, Victoria, Australia
Issue Date: 16-May-1996
Publication information: Advances in Experimental Medicine and Biology; 396(): 93-103
Abstract: There is a large body of evidence to support the concept of a relationship between brain Ang II and catecholamine systems. This interaction may participate in some central actions of Ang II such as cardiovascular control, dipsogenesis, and complex behaviours. It also extends to the nigrostriatal dopaminergic system which bear AT1 receptors, both on their cell bodies in the substantia nigra presynaptically, and on their terminals in the striatum, where Ang II can markedly potentiate DA release. This observation suggests that drugs which modulate central Ang II may be useful in regulating central dopaminergic activity.
Gov't Doc #: 8726689
Journal: Advances in Experimental Medicine and Biology
Type: Journal Article
Subjects: Angiotensin II.metabolism
Appears in Collections:Journal articles

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