Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13419
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dc.contributor.authorJenkins, T Aen
dc.contributor.authorChai, Syn Yen
dc.contributor.authorHowells, David Williamen
dc.contributor.authorMendelsohn, Frederick AOen
dc.date.accessioned2015-05-16T03:15:59Z
dc.date.available2015-05-16T03:15:59Z
dc.date.issued1995-09-11en
dc.identifier.citationBrain Research; 691(1-2): 213-6en
dc.identifier.govdoc8590055en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/13419en
dc.description.abstractIn rats with unilateral 6-hydroxydopamine lesions in the nigrostriatal pathway, injection of angiotensin II (2 nmol) into the unlesioned striatum elicited dose-related tight rotations ipsilateral to the lesion. This rotation was suppressed by coadministration of the angiotensin AT1 receptor antagonist, losartan (2 nmol), which had no significant effect when injected alone. Preadministration of the dopamine antagonist, haloperidol (2 mg/kg i.p.) completely blocked angiotensin II-induced turning at doses of 0.3-3 nmol, and partially at 10 nmol. These results further confirm the hypothesis that Ang II is intrinsically involved in modulating dopamine release in the striatum, an effect which is mediated predominantly by AT1 receptors.en
dc.language.isoenen
dc.subject.otherAngiotensin II.antagonists & inhibitors.pharmacologyen
dc.subject.otherAnimalsen
dc.subject.otherBiphenyl Compounds.pharmacologyen
dc.subject.otherCorpus Striatum.drug effectsen
dc.subject.otherDopamine.physiologyen
dc.subject.otherFunctional Laterality.physiologyen
dc.subject.otherHaloperidol.pharmacologyen
dc.subject.otherImidazoles.pharmacologyen
dc.subject.otherLosartanen
dc.subject.otherMaleen
dc.subject.otherMotor Activity.drug effectsen
dc.subject.otherOxidopamineen
dc.subject.otherRatsen
dc.subject.otherRats, Sprague-Dawleyen
dc.subject.otherRotationen
dc.subject.otherSubstantia Nigra.drug effectsen
dc.subject.otherTetrazoles.pharmacologyen
dc.titleIntrastriatal angiotensin II induces turning behaviour in 6-hydroxydopamine lesioned rats.en
dc.typeJournal Articleen
dc.identifier.journaltitleBrain Researchen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australiaen
dc.description.pages213-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/8590055en
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.cerifentitytypePublications-
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