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Title: Diabetic vascular hypertrophy and albuminuria: effect of angiotensin converting enzyme inhibition.
Austin Authors: Allen, Terri J;Hulthen, U L;Rumble, J R;Jasik, M;Cooper, Mark E
Affiliation: Department of Medicine, University of Melbourne, Austin, Australia
Issue Date: 12-Oct-1995
Publication information: Journal of Diabetes and Its Complications; 9(4): 318-22
Abstract: The role of angiotensin-converting enzyme (ACE) inhibition with ramipril on mesenteric vascular hypertrophy and urinary albumin excretion was explored in a normotensive model of experimental diabetes. Serial measurements of albuminuria were performed in Sprague-Dawley control, diabetic rats, and diabetic rats treated with ramipril. Over 24 weeks, urinary albumin excretion showed a continuous rise in the untreated diabetic rats. Ramipril prevented the increase in albuminuria over the whole study period. After 6 months, animals were perfused with glutaraldehyde and sacrificed for measurement of mesenteric vessel wall/lumen ratio and kidney weight. Diabetes was associated with increased mesenteric wall/lumen ratio and kidney weight. ACE inhibition, despite no effect on glycemic control, attenuated mesenteric vascular hypertrophy but did not decrease kidney weight. In addition to the well-described renoprotective effects of ACE inhibition in diabetes, this class of agents may have a favorable effect on diabetic vascular disease.
Gov't Doc #: 8573756
Journal: Journal of diabetes and its complications
Type: Journal Article
Subjects: Albuminuria.prevention & control
Angiotensin-Converting Enzyme Inhibitors.therapeutic use
Blood Glucose.metabolism
Body Weight.drug effects
Diabetes Mellitus, Experimental.pathology.physiopathology
Diabetic Nephropathies.prevention & control
Hemoglobin A, Glycosylated.analysis
Kidney.drug effects
Muscle, Smooth, Vascular.drug effects.pathology
Organ Size.drug effects
Ramipril.therapeutic use
Rats, Sprague-Dawley
Reference Values
Splanchnic Circulation.drug effects
Systole.drug effects
Appears in Collections:Journal articles

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